Instability at chromosomal fragile sites.

Instability at chromosomal fragile sites. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Instability at chromosomal fragile sites. Abstract Text:

T W Glover,

Chromosomal fragile sites are loci that are especially prone to forming gaps or breaks on metaphase chromosomes when cells are cultured under conditions that inhibit DNA replication or repair. The relationship of "rare" folate sensitive fragile sites with (CCG)n expansion and, in some cases, genetic disease is well established. Although they comprise the vast majority of fragile sites, much less is known at the molecular level about the "common" fragile sites. These fragile sites may be seen on all chromosomes as a constant feature. In addition to forming fragile sites on metaphase chromosomes, they have been shown to display a number of characteristics of unstable and highly recombinogenic DNA in vitro, including chromosome rearrangements, sister chromatid exchanges and, more recently, intrachromosomal gene amplification. Only one such fragile site, FRA3B at 3p14.2, has been extensively investigated at the molecular level. It extends over a broad region of possibly 500 kb, and no trinucleotide or other simple repeat motifs have been identified in the region. FRA3B has recently been shown to lie within the FHIT gene locus. This region and the FHIT gene are unstable in a number of tumors and tumor cell lines. It thus appears that common fragile sites are also associated with unstable regions of DNA in vivo, at least in some tumor cells, and may cause this instability. Current challenges include determining the mechanism of fragile site expression and instability, and both the environmental and genetic factors that influence this process. Candidate factors include those genes involved in DNA repair and cell cycle and common carcinogens such as those in cigarette smoke.

Instability at chromosomal fragile sites. Publishing Authors By Initials

TW Glover,

For similar proteins research abstracts see: proteins research

PUBMED ID PMID:

MEDLINE DATE:

Instability at chromosomal fragile sites. Journal Published:

PUBLICATION TYPE: Review

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 154

Page Numbers: 185-99

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1998

Instability at chromosomal fragile sites. Information

Number of References: 69

LANGUAGE: eng

NlmUniqueID: 44671

Instability at chromosomal fragile sites. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Instability at chromosomal fragile sites. Information

Substance Name: Acid Anhydride Hydrolases

Registry Number: EC 3.6.-

Grant and Affiliation Information for Instability at chromosomal fragile sites.

AFFILIATION: Department of Pediatrics, University of Michigan, Ann Arbor 48109-0618, USA.

Country: GERMANY

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Recent Results Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Instability at chromosomal fragile sites Related Publications

• A novel VEGFR3 mutation causes Milroy disease.
• A technique for pulmonary segmental delineation.
• Amniotic fluid testosterone: relationship with cortisol and gestational age.
• Antenatal maternal stress and long-term effects on child neurodevelopment: how and why?
• Assessing the influence of scanner background noise on auditory processing. I. An fMRI study comparing three experimental designs with varying degrees of scanner noise.
• Assessing the influence of scanner background noise on auditory processing. II. An fMRI study comparing auditory processing in the absence and presence of recorded scanner noise using a sparse design.
• Changing cultures: enhancing mental health and wellbeing of refugee young people through education and training.
• Chemistry of 4-alkylaryloxenium ion "precursors": sound and fury signifying something?
• Chromosome fragile sites.
• Controlled inspiration depth reduces variance in breath-holding-induced BOLD signal.
• DSAS-6 organizes a tube-like centriole precursor, and its absence suggests modularity in centriole assembly.
• Effect of the hypocholesterolemic drug, AY 9944, on the absorption of retinol in the rat.
• Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain.
• Frontostriatal connectivity and its role in cognitive control in parent-child dyads with ADHD.
• Macular degeneration: types, causes, and possible interventions.
• Management of allergic sinusitis.
• Maternal stress during pregnancy predicts cognitive ability and fearfulness in infancy.
• Parental and adolescent smoking: does the association vary with gender and ethnicity?
• Poultry disease problems in Ontario.
• ROCK-II mediates colon cancer invasion via regulation of MMP-2 and MMP-13 at the site of invadopodia as revealed by multiphoton imaging.
• Reducing interscanner variability of activation in a multicenter fMRI study: controlling for signal-to-fluctuation-noise-ratio (SFNR) differences.
• Relationship between hypoxia, oxygen consumption and body temperature.
• Restricted field of view magnetic resonance imaging of a dynamic time series.
• Spatiotemporal patterns of neurogenesis in the appendicularian Oikopleura dioica.
• State mental health policy: critical priorities confronting state mental health agencies.
• The clinical and economic potential of hyperbaric oxygen therapy in the treatment of diabetic ulceration and other conditions.
• The personal librarian program:an evaluation of a cushing/whitney medical library outreach initiative.
• The role of steric effects in the direct mutagenicity of N-acyloxy-N-alkoxyamides.
• Three-dimensional spiral technique for high-resolution functional MRI.
• [Not Available.]