Insignificant seasonal and geographical variation in incidence of biliary atresia in Japan: a regional survey of over 20 years.

Insignificant seasonal and geographical variation in incidence of biliary atresia in Japan: a regional survey of over 20 years. Research Abstract Details 

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Insignificant seasonal and geographical variation in incidence of biliary atresia in Japan: a regional survey of over 20 years. Abstract Text:

Hidemi Wada,Toshihiro Muraji,Akiko Yokoi,Tatsuya Okamoto,Shiiki Sato,Shigeru Takamizawa,Jiro Tsugawa,Eiji Nishijima,Hidemi Wada,Toshihiro Muraji,Akiko Yokoi,Tatsuya Okamoto,Shiiki Sato,Shigeru Takamizawa,Jiro Tsugawa,Eiji Nishijima,

PURPOSE: Biliary atresia (BA) is the leading cause of obstructive jaundice in the newborn and the major indication for liver transplantation in Japan. Viral infection has been implicated in its etiology because of seasonality and space clustering. However, this has been controversial among whites. The present study investigates space-time clustering of the incidence of BA in Japan. METHODS: Birth prevalence rates of BA were analyzed in infants born in Hyogo prefecture between 1985 and 2004 to assess time clustering among 3 seasons. The birth prevalence rates were also analyzed for space clustering between the northern (Hokkaido) and the southern islands (Kyushu) (difference of latitude, 10 degrees ) based on the Japanese Biliary Atresia Society Survey 1996-2004. We compared the prevalence rates between these groups using relative risks (RRs) calculated from 2 x 2 contingency tables. RESULTS: One hundred nineteen infants were born with BA in Hyogo (1.1/10000 live births). Seasonal clustering in April to July did not significantly differ from that of the reference period (RR, 1.45; 95% confidence interval, 0.93-2.27). Based on Japanese registry data, space clustering between the northern and southern islands did not significantly differ (RR, 1.24; 95% confidence interval, 0.83-1.86). CONCLUSIONS: Neither seasonal nor spatial clustering was statistically proven in Japan.

Insignificant seasonal and geographical variation in incidence of biliary atresia in Japan: a regional survey of over 20 years. Publishing Authors By Initials

H Wada,T Muraji,A Yokoi,T Okamoto,S Sato,S Takamizawa,J Tsugawa,E Nishijima,H Wada,T Muraji,A Yokoi,T Okamoto,S Sato,S Takamizawa,J Tsugawa,E Nishijima,

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Insignificant seasonal and geographical variation in incidence of biliary atresia in Japan: a regional survey of over 20 years. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of pediatric surgery

VOLUME: 42

Page Numbers: 2090-2

Journal Abbreviation: J. Pediatr. Surg.

ISSN: 1531-5037

DAY: 17

MONTH: Dec

YEAR: 2007

Insignificant seasonal and geographical variation in incidence of biliary atresia in Japan: a regional survey of over 20 years. Information

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LANGUAGE: eng

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AFFILIATION: Division of Pediatric Surgery, Kobe Children's Hospital, Kobe, Hyogo 654-0081, Japan. wada_kch@hp.pref.hyogo.jp

Country: United States

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MEDLINETA: J Pediatr Surg

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