Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease.

Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Research Abstract Details 

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Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Abstract Text:

B F Boeve,D W Dickson,E J Olson,J W Shepard,M H Silber,T J Ferman,J E Ahlskog,E E Benarroch,

BACKGROUND AND PURPOSE: Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia reflecting changes in the brain, but which specific neuronal networks are involved in human RBD pathogenesis has not yet been determined. To date, only one case of idiopathic RBD has undergone autopsy, in which "incidental Lewy body disease" was found. Due to the severe neuronal loss and gliosis in the substantia nigra (SN) and locus ceruleus (LC) in this case, degeneration of brainstem monoaminergic neurons was postulated as the underlying substrate for RBD. Additional cases of idiopathic RBD with neuropathologic examination may help clarify which key brainstem structures are involved. PATIENT AND METHODS: Case report with neuropathologic analysis. RESULTS: A man with polysomnographically proven RBD (onset age 57 years), but no other neurologic signs or symptoms, underwent neuropathologic examination upon his death at age 72. Histopathologic analysis showed Lewy body disease, but no significant neuronal loss or gliosis was present in the SN or LC. CONCLUSIONS: This case represents another example of Lewy body disease associated with RBD. The minimal degenerative changes in the SN and LC call into question the role of these nuclei in RBD, at least in our case. We suggest additional cases of idiopathic RBD undergo neuropathologic analyses to better delineate the neurologic substrate of this intriguing parasomnia.

Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Publishing Authors By Initials

BF Boeve,DW Dickson,EJ Olson,JW Shepard,MH Silber,TJ Ferman,JE Ahlskog,EE Benarroch,

For similar proteins: nerve tissue proteins: synucleins: alpha-synuclein research abstracts see: proteins: nerve tissue proteins: synucleins: alpha-synuclein research

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Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Sleep medicine

VOLUME: 8

Page Numbers: 60-4

Journal Abbreviation: Sleep Med.

ISSN: 1389-9457

DAY: 6

MONTH: 12

YEAR: 2006

Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Information

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LANGUAGE: eng

NlmUniqueID: 100898759

Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Keywords Mesh Terms:

KEYWORDS: alpha-Synuclein

MESH TERMS: metabolism

Chemical & Substance for Abstract: Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. Information

Substance Name: alpha-Synuclein

Registry Number: 0

Grant and Affiliation Information for Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease.

AFFILIATION: Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA. bboeve@mayo.edu

Country: Netherlands

AGENCY: United States NIA

GRANT: R01 AG15866

ACRONYM: AG

MEDLINETA: Sleep Med

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