Insight into the genetics of diabetic nephropathy through the study of mice.

Insight into the genetics of diabetic nephropathy through the study of mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Insight into the genetics of diabetic nephropathy through the study of mice. Abstract Text:

Matthew D Breyer,Zhonghua Qi,Elena E Tchekneva,Raymond C Harris,Matthew D Breyer,Zhonghua Qi,Elena E Tchekneva,Raymond C Harris,Matthew D Breyer,Zhonghua Qi,Elena E Tchekneva,Raymond C Harris,Matthew D Breyer,Zhonghua Qi,Elena E Tchekneva,Raymond C Harris,

PURPOSE OF REVIEW: To discuss mouse models of diabetic nephropathy and their use in discovering genetic risk factors predisposing to diabetic nephropathy. RECENT FINDINGS: Despite occurring in only 10-40% of diabetic patients, diabetic nephropathy is the largest single cause of end stage renal disease in the USA. Accumulated evidence points to critical genetic factors that predispose a subset of diabetic patients to nephropathy.Defining the genes that confer risk for nephropathy in human populations has proven challenging. The use of robust genetic reagents available in the laboratory mouse provides a complementary approach to defining genes that predispose to diabetic nephropathy in mice and humans. These findings support the existence of dominant mutations predisposing to diabetic nephropathy in mice as well as substantiating an important role for eNOS in forestalling the development of diabetic nephropathy. SUMMARY: When studied for a sufficient duration of diabetic hyperglycemia, some strains of mice exhibit changes similar to those of human diabetic nephropathy. The unique genetic reagents in mice should help accelerate the identification of genes predisposing to diabetic nephropathy.

Insight into the genetics of diabetic nephropathy through the study of mice. Publishing Authors By Initials

MD Breyer,Z Qi,EE Tchekneva,RC Harris,MD Breyer,Z Qi,EE Tchekneva,RC Harris,MD Breyer,Z Qi,EE Tchekneva,RC Harris,MD Breyer,Z Qi,EE Tchekneva,RC Harris,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Insight into the genetics of diabetic nephropathy through the study of mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current opinion in nephrology and hypertension

VOLUME: 17

Page Numbers: 82-6

Journal Abbreviation: Curr. Opin. Nephrol. Hypertens

ISSN: 1062-4821

DAY: 19

MONTH: Jan

YEAR: 2008

Insight into the genetics of diabetic nephropathy through the study of mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9303753

Insight into the genetics of diabetic nephropathy through the study of mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Insight into the genetics of diabetic nephropathy through the study of mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Insight into the genetics of diabetic nephropathy through the study of mice.

AFFILIATION: aBiotherapeutics Discovery Research Eli Lilly and Company, Indianapolis, Indiana, USA bDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Curr Opin Nephrol Hypertens

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Insight into the genetics of diabetic nephropathy through the study of mice Related Publications

• A clonal chondrocytic cell line derived from BMP-2/T antigen-expressing transgenic mouse.
• Activation of oxygen nucleophiles in enzyme catalysis.
• Autoregulation of mouse BMP-2 gene transcription is directed by the proximal promoter element.
• Biomechanical implications of the negative heel rocker sole shoe: gait kinematics and kinetics.
• Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts.
• Bone morphogenetic protein 2 transcripts in rapidly developing deer antler tissue contain an extended 5' non-coding region arising from a distal promoter.
• CFTR expression does not influence glycosylation of an epitope-tagged MUC1 mucin in colon carcinoma cell lines.
• COX-2 and the kidney.
• Clonal osteoblastic cell lines from p53 null mouse calvariae are immortalized and dependent on bone morphogenetic protein 2 for mature osteoblastic phenotype.
• Dense core vesicles resemble active-zone transport vesicles and are diminished following synaptogenesis in mature hippocampal slices.
• Diabetes, hyperglycemia, and inflammation in older individuals: the health, aging and body composition study.
• Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study.
• Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages.
• Exaggerated response to mild stress in rats fed high-fat diet.
• Gene expression profiling in osteoblast biology: bioinformatic tools.
• Genetics of body condition score in New Zealand dairy cows.
• Glycemia and cognitive function in older adults using glucose-lowering drugs.
• Gyrodactylid developmental biology: historical review, current status and future trends.
• Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance.
• Immunoregulation in pancreatic cancer patients.
• Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice.
• Leisure-time exercise and overall physical activity in older women caregivers and non-caregivers from the Caregiver-SOF Study.
• Plasticity of perisynaptic astroglia during synaptogenesis in the mature rat hippocampus.
• Pondermotive forces with slow light.
• Renal cortical cyclooxygenase 2 expression is differentially regulated by angiotensin II AT(1) and AT(2) receptors.
• Role of EGF receptor activation in angiotensin II-induced renal epithelial cell hypertrophy.
• The contribution of tandem repeat number to the O-glycosylation of mucins.
• Therapeutic Strategies for Localized Prostate Cancer II: Perineal Prostatectomy, X-Rays, Protons, Neutrons, and Combination Brachytherapy.
• Visualizing pancreatic beta-cell mass with [11C]DTBZ.
• c-erbB-2 and episialin challenge host immune response by HLA class I expression in human non-small-cell lung cancer.