Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus.

Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. Research Abstract Details 

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Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. Abstract Text:

Nils H Nicolay,Daniel Hertle,Wolfgang Boehmerle,Felix M Heidrich,Mark Yeckel,Barbara E Ehrlich,

Calcium (Ca(2+)) release from intracellular stores plays a crucial role in many cellular functions in the brain. These intracellular signals have been shown to be transmitted within and between cells. We report a non-uniform distribution of proteins essential for Ca(2+) signaling in acutely prepared brain slice preparations and organotypic slice cultures, both made from rat hippocampus. The Type I inositol-1,4,5 trisphosphate receptor (InsP(3)R1) is the main InsP(3)R subtype in neurons. Immunohistochemistry experiments showed a prominent expression of InsP(3)R1 in the CA1 region of the hippocampus whereas the CA3 region and dentate gyrus (DG) showed only moderate immunoreactivity. In contrast, chromogranin B (CGB), a protein binding to the InsP(3)R1 on the luminal side of the endoplasmic reticular membrane was enriched in the CA3 region whereas DG and the CA1 region showed only faint CGB signals. The neuronal kinases leading to the formation of inositol-1,4,5 trisphosphate (InsP(3)), phosphatidylinositol-4-kinase (PI4K), and phosphatidylinositol-4-phosphate-5-kinase (PIPK), showed strong immunoreactivity throughout all hippocampal cell fields with differences in the subcellular distribution. Moreover, a distinct band of strong CGB and PIPK immunoreactivity was observed in the CA3 region that coincides with the mossy fiber tract (stratum lucidum). These data show differential expression of the components of the signaling toolkit leading to InsP(3)-mediated Ca(2+) release in cells of the hippocampus. The regulation of these differences may play an important role in various neuropathologic conditions such as Alzheimer's disease, epilepsy, or schizophrenia.

Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. Publishing Authors By Initials

NH Nicolay,D Hertle,W Boehmerle,FM Heidrich,M Yeckel,BE Ehrlich,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroscience research

VOLUME: 85

Page Numbers: 2026-36

Journal Abbreviation: J. Neurosci. Res.

ISSN: 0360-4012

DAY: 3

MONTH: Jul

YEAR: 2007

Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600111

Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: metabolism

Chemical & Substance for Abstract: Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus. Information

Substance Name: 1-phosphatidylinositol-4-phosphate 5-kin

Registry Number: EC 2.7.1.68

Grant and Affiliation Information for Inositol 1,4,5 trisphosphate receptor and chromogranin B are concentrated in different regions of the hippocampus.

AFFILIATION: Department of Pharmacology, Yale University, New Haven, Connecticut 06520-8066, USA.

Country: United States

AGENCY: United States NIMH

GRANT: R01 MH067830

ACRONYM: MH

MEDLINETA: J Neurosci Res

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