Inorganic-organic polymer hybrid scaffold for tissue engineering--II: partial enzymatic degradation of hydroxyapatite-chitosan hybrid.

Inorganic-organic polymer hybrid scaffold for tissue engineering--II: partial enzymatic degradation of hydroxyapatite-chitosan hybrid. Research Abstract Details 

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Inorganic-organic polymer hybrid scaffold for tissue engineering--II: partial enzymatic degradation of hydroxyapatite-chitosan hybrid. Abstract Text:

Wanpen Tachaboonyakiat,Takeshi Serizawa,Mitsuru Akashi,

This article describes the preparation of porous chitosan, a hydroxyapatite hybrid, by partial enzymatic degradation. Two enzymes, chitosanase and lysozyme, were selected to hydrolyze a chitosan-reinforced matrix and create pores within the chitosan-hydroxyapatite composite. The degree of enzymatic hydrolysis of the chitosan-hydroxyapatite composite was determined by measuring the % weight loss of the chitosan matrix and the hydroxyapatite component. Hydroxyapatite loss from the chitosan matrix increased with the degree of enzymatic hydrolysis of the chitosan-reinforced matrix. After hydrolysis, the composite was further characterized by FTIR. Quantitative analysis revealed a decrease in the characteristic pyranose ring peak (1072 cm(-1)), compared with Po4(2-) (1110 cm(-1)), showing that the chitosan matrices were enzymatically hydrolyzed. The surface of the porous chitosan-hydroxyapatite composite, prepared by controlling enzymatic hydrolysis, was also observed by SEM.

Inorganic-organic polymer hybrid scaffold for tissue engineering--II: partial enzymatic degradation of hydroxyapatite-chitosan hybrid. Publishing Authors By Initials

W Tachaboonyakiat,T Serizawa,M Akashi,

For similar investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research abstracts see: investigative techniques: clinical laboratory techniques: culture techniques: tissue engineering research

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Inorganic-organic polymer hybrid scaffold for tissue engineering--II: partial enzymatic degradation of hydroxyapatite-chitosan hybrid. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 13

Page Numbers: 1021-32

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2002

Inorganic-organic polymer hybrid scaffold for tissue engineering--II: partial enzymatic degradation of hydroxyapatite-chitosan hybrid. Information

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LANGUAGE: eng

NlmUniqueID: 9007393

Inorganic-organic polymer hybrid scaffold for tissue engineering--II: partial enzymatic degradation of hydroxyapatite-chitosan hybrid. Keywords Mesh Terms:

KEYWORDS: Tissue Engineering

MESH TERMS: methods

Chemical & Substance for Abstract: Inorganic-organic polymer hybrid scaffold for tissue engineering--II: partial enzymatic degradation of hydroxyapatite-chitosan hybrid. Information

Substance Name: Muramidase

Registry Number: EC 3.2.1.17

Grant and Affiliation Information for Inorganic-organic polymer hybrid scaffold for tissue engineering--II: partial enzymatic degradation of hydroxyapatite-chitosan hybrid.

AFFILIATION: Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, Japan.

Country: Netherlands

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MEDLINETA: J Biomater Sci Polym Ed

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