Inoprotection: the perioperative role of levosimendan.

Inoprotection: the perioperative role of levosimendan. Research Abstract Details 

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Inoprotection: the perioperative role of levosimendan. Abstract Text:

P E Soeding,C F Royse,C E Wright,A G Royse,J A Angus,P E Soeding,C F Royse,C E Wright,A G Royse,J A Angus,

Levosimendan is emerging as a novel cardioprotective inotrope. Levosimendan augments myocardial contractility by sensitising contractile myofilaments to calcium without increasing myosin adenosine triphosphatase activity or oxygen consumption. Levosimendan activates cellular adenosine triphosphate-dependent potassium channels, a mechanism which is postulated to protect cells from ischaemia in a manner similar to ischaemic preconditioning. Levosimendan may therefore protect the ischaemic myocardium during ischaemia-reperfusion as well as improve the contractile function of the heart. Adenosine triphosphate-dependent potassium channel activation by levosimendan may also be protective in other tissues, such as coronary vascular endothelium, kidney and brain. Clinical trials in patients with decompensated heart failure and myocardial ischaemia show levosimendan to improve haemodynamic performance and potentially improve survival. This paper reviews the known pharmacology of levosimendan, the clinical experience with the drug to date and the potential use of levosimendan as a cardioprotective agent during surgery.

Inoprotection: the perioperative role of levosimendan. Publishing Authors By Initials

PE Soeding,CF Royse,CE Wright,AG Royse,JA Angus,PE Soeding,CF Royse,CE Wright,AG Royse,JA Angus,

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Inoprotection: the perioperative role of levosimendan. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Anaesthesia and intensive care

VOLUME: 35

Page Numbers: 845-62

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ISSN: 0310-057X

DAY: 18

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 342017

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Grant and Affiliation Information for Inoprotection: the perioperative role of levosimendan.

AFFILIATION: Cardiovascular Therapeutics Unit, Department of Pharmacology, University of Melbourne, Melbourne, Victoria, Australia.

Country: Australia

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MEDLINETA: Anaesth Intensive Care

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