Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model.

Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. Abstract Text:

Toshihiro Matsuo,Takashi Sugita,Tadahiko Kubo,Yuji Yasunaga,Mitsuo Ochi,Teruo Murakami,

Small-sized magnetic liposomes with incorporated recombinant human bone morphogenetic protein-2 (rhBMP-2) were prepared, and the efficiency for bone formation after topical injection was evaluated in a rat bone-defect model. A critical-sized segmental bone defect was created in the mid-part of the femoral shaft, and a permanent magnet was attached. Topical injection onto the defects was performed with different liposomal preparations (nonmagnetic and magnetic liposomes) using different treatment modalities (different doses and different treatment timing of rhBMP-2). Weekly evaluations were made radiographically and microcomputed tomographically, histologically, and/or by mechanical testing at 9 weeks after surgery. A single topical application of magnetic liposomes with an appropriate amount of rhBMP-2 (approximately 3 microg) incorporated under magnetic induction immediately after surgery was effective for new bone formation. The combined treatment of topical magnetic rhBMP-2 liposomes and magnetic implantation at the injury site was effective for the treatment of bone defects. This injectable carrier for BMP is expected to have many advantages over solid carriers because it can be prepared easily and can be less invasively applied to the injured site at any time after surgery.

Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. Publishing Authors By Initials

T Matsuo,T Sugita,T Kubo,Y Yasunaga,M Ochi,T Murakami,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

PUBMED ID PMID:

MEDLINE DATE:

Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedical materials research. Part A

VOLUME: 66

Page Numbers: 747-54

Journal Abbreviation:

ISSN: 1549-3296

DAY: 15

MONTH: Sep

YEAR: 2003

Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101234237

Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model. Information

Substance Name: recombinant human bone morphogenetic pro

Registry Number: 0

Grant and Affiliation Information for Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model.

AFFILIATION: Department of Orthopaedic Surgery, Programs for Applied Biomedicine, Division of Clinical Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. ZVT01540@nifty.ne.jp

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biomed Mater Res A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model Related Publications

• Anatomical study of perineal pelvic lymphadenectomy.
• Asymmetric synthesis of 3,4-dihydrocoumarins by rhodium-catalyzed reaction of 3-(2-hydroxyphenyl)cyclobutanones.
• Cardiac troponin risk stratification based on 99th percentile reference cutoffs in patients with ischemic symptoms suggestive of acute coronary syndrome: influence of estimated glomerular filtration rates.
• Clinical significance of neutrophil apoptosis in peripheral blood of patients with type 2 diabetes mellitus.
• Evaluation of novel dry eye model: preganglionic parasympathetic denervation in rabbit.
• Functional interaction of hepatitis C Virus NS5B with Nucleolin GAR domain.
• Highly sensitive upregulation of apolipoprotein A-IV by peroxisome proliferator-activated receptor alpha (PPARalpha) agonist in human hepatoma cells.
• In vivo observations of a case of chlorpromazine deposits in the cornea using an HRT II Rostock corneal module.
• Injectable magnetic liposomes as a novel carrier of recombinant human BMP-2 for bone formation in a rat bone-defect model.
• Neurinoma of the greater superficial petrosal nerve developed acute facial palsy: case report and review of the literature.
• Ozone micro-bubble disinfection method for wastewater reuse system.
• Prosthetic soft contact lenses in Japan.
• Pyrrolizidine Alkaloids from Ligularia japonica.
• Quantum spin Hall effect and enhanced magnetic response by spin-orbit coupling.
• Radiofrequency ablation of a cervical osteoid osteoma: a trans-thyroid approach.
• Real-time monitoring of antibody secretion from B-cells on a microchip stimulated with a minute amount of mitogen.
• Rhodium-catalyzed carbonylation of spiropentanes.
• Simplified laparoscopic duodenal switch.
• Stereoselective synthesis of 3-alkylideneoxindoles by rhodium-catalyzed cyclization reaction of 2-alkynylaryl isocyanates with aryl- and alkenylboronic acids.
• Stereoselective synthesis of alpha-allenols by rhodium-catalyzed reaction of alkynyl oxiranes with arylboronic acids.
• Stereoselective synthesis of trisubstituted alkenylboranes by palladium-catalysed reaction of alkynyltriarylborates with aryl halides.
• Stress resistance in long-lived mouse models.
• Successful treatment with voriconazole of Aspergillus meningitis in a patient with acute myeloid leukemia.
• The usefulness of (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) and a comparison of (18)F-FDG-pet with (67)gallium scintigraphy in the evaluation of lymphoma: relation to histologic subtypes based on the World Health Organization c
• Thrombin regulates the function of human blood dendritic cells.
• [A case of cardiac angiosarcoma successfully treated with docetaxel]
• [Idiopathic pericarditis]
• [Present status and problems of schools for physically disabled children from the viewpoint of a school physician]
• [Safety and structural analysis of polymers produced in manufacturing process of alpha-lipoic acid]
• [Urinalysis as mass screening for kidney diseases in school children]