Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size.

Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size. Research Abstract Details 

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Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size. Abstract Text:

Elena F Burguera,Hockin H K Xu,Limin Sun,Elena F Burguera,Hockin H K Xu,Limin Sun,

Calcium phosphate cement (CPC) sets in situ and forms apatite with excellent osteoconductivity and bone-replacement capability. The objectives of this study were to formulate an injectable tetracalcium phosphate-dicalcium phosphate cement (CPC(D)), and investigate the powder/liquid ratio and needle-size effects. The injection force (mean +/- SD; n = 4) to extrude the paste increased from (8 +/- 2) N using a 10-gauge needle to (144 +/- 17) N using a 21-gauge needle (p < 0.05). With the 10-gauge needle, the mass percentage of extruded paste was (95 +/- 4)% at a powder/liquid ratio of 3; it decreased to (70 +/- 12)% at powder/liquid = 3.5 (p < 0.05). A relationship was established between injection force, F, and needle lumen cross-sectional area, A: F = 5.0 + 38.7/A(0.8). Flexural strength, S, (mean +/- SD; n = 5) increased from (5.3 +/- 0.8) MPa at powder/liquid= 2 to (11.0 +/- 0.8) MPa at powder/liquid = 3.5 (p < 0.05). Pore volume fraction, P, ranged from 62.4% to 47.9%. A relationship was established: S = 47.7 x (1 - P)(2.3). The strength of the injectable CPC(D) matched/exceeded the reported strengths of sintered porous hydroxyapatite implants that required machining. The novel injectable CPC(D) with a relatively high strength may be useful in filling defects with limited accessibility such as periodontal repair and tooth root-canal fillings, and in minimally-invasive techniques such as percutaneous vertebroplasty to fill the lesions and to strengthen the osteoporotic bone. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008.

Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size. Publishing Authors By Initials

EF Burguera,HH Xu,L Sun,EF Burguera,HH Xu,L Sun,

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Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedical materials research. Part B,

VOLUME: 84

Page Numbers: 493-502

Journal Abbreviation: J. Biomed. Mater. Res. Part B

ISSN: 1552-4973

DAY: 14

MONTH: Feb

YEAR: 2008

Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Injectable calcium phosphate cement: Effects of powder-to-liquid ratio and needle size.

AFFILIATION: Paffenbarger Research Center, American Dental Association Foundation, National Institute of Standards and Technology, Gaithersburg, Maryland 20899-8546.

Country: United States

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MEDLINETA: J Biomed Mater Res B Appl Biom

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