Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity.

Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Research Abstract Details 

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Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Abstract Text:

Mari Tenno,Kazuaki Ohtsubo,Fred K Hagen,David Ditto,Alexander Zarbock,Patrick Schaerli,Ulrich H von Andrian,Klaus Ley,Dzung Le,Lawrence A Tabak,Jamey D Marth,Mari Tenno,Kazuaki Ohtsubo,Fred K Hagen,David Ditto,Alexander Zarbock,Patrick Schaerli,Ulrich H von Andrian,Klaus Ley,Dzung Le,Lawrence A Tabak,Jamey D Marth,

Core-type protein O glycosylation is initiated by polypeptide N-acetylgalactosamine (GalNAc) transferase (ppGalNAcT) activity and produces the covalent linkage of serine and threonine residues of proteins. More than a dozen ppGalNAcTs operate within multicellular organisms, and they differ with respect to expression patterns and substrate selectivity. These distinctive features imply that each ppGalNAcT may differentially modulate regulatory processes in animal development, physiology, and perhaps disease. We found that ppGalNAcT-1 plays key roles in cell and glycoprotein selective functions that modulate the hematopoietic system. Loss of ppGalNAcT-1 activity in the mouse results in a bleeding disorder which tracks with reduced plasma levels of blood coagulation factors V, VII, VIII, IX, X, and XII. ppGalNAcT-1 further supports leukocyte trafficking and residency in normal homeostatic physiology as well as during inflammatory responses, in part by providing a scaffold for the synthesis of selectin ligands expressed by neutrophils and endothelial cells of peripheral lymph nodes. Animals lacking ppGalNAcT-1 are also markedly impaired in immunoglobulin G production, coincident with increased germinal center B-cell apoptosis and reduced levels of plasma B cells. These findings reveal that the initiation of protein O glycosylation by ppGalNAcT-1 provides a distinctive repertoire of advantageous functions that support vascular responses and humoral immunity.

Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Publishing Authors By Initials

M Tenno,K Ohtsubo,FK Hagen,D Ditto,A Zarbock,P Schaerli,UH von Andrian,K Ley,D Le,LA Tabak,JD Marth,M Tenno,K Ohtsubo,FK Hagen,D Ditto,A Zarbock,P Schaerli,UH von Andrian,K Ley,D Le,LA Tabak,JD Marth,

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Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular and cellular biology

VOLUME: 27

Page Numbers: 8783-96

Journal Abbreviation: Mol. Cell. Biol.

ISSN: 1098-5549

DAY: 8

MONTH: 10

YEAR: 2007

Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity. Information

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LANGUAGE: eng

NlmUniqueID: 8109087

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Grant and Affiliation Information for Initiation of protein O glycosylation by the polypeptide GalNAcT-1 in vascular biology and humoral immunity.

AFFILIATION: Howard Hughes Medical Institute, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK48247

ACRONYM: DK

MEDLINETA: Mol Cell Biol

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