Initiating the uninitiated: replication of damaged DNA and carcinogenesis.

Initiating the uninitiated: replication of damaged DNA and carcinogenesis. Research Abstract Details 

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Initiating the uninitiated: replication of damaged DNA and carcinogenesis. Abstract Text:

William K Kaufmann,William K Kaufmann,

Cancer is a genetic disease and carcinogenesis is the process whereby the relevant genetic alterations are acquired. Environmental carcinogens may damage DNA to induce mutations and chromosomal aberrations as permanent heritable changes in the genome that initiate carcinogenesis. For many carcinogens initiation of carcinogenesis requires the initiation of DNA replication suggesting that genetic alterations are fixed in the genome during replication of damaged DNA. It is of great interest to understand the mechanisms whereby carcinogen-induced damage to DNA causes mutations and chromosomal aberrations and how cells may resist such events. It is clear now that cells express a complex repertoire of responses to DNA damage including several pathways of DNA repair and cell cycle checkpoints that protect against carcinogenesis. This commentary is concerned with the protective influence of DNA damage checkpoints that delay or arrest progression through the cell division cycle and especially with the responses of S phase cells to the environmental carcinogens UV and benzo[a]pyrene diolepoxide I (BPDE). Recent studies indicate that checkpoint responses may act at the very point of replication of damaged DNA to slow DNA chain elongation, inhibit replicon initiation and suppress initiation of carcinogenesis.

Initiating the uninitiated: replication of damaged DNA and carcinogenesis. Publishing Authors By Initials

WK Kaufmann,WK Kaufmann,

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Initiating the uninitiated: replication of damaged DNA and carcinogenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell cycle (Georgetown, Tex.)

VOLUME: 6

Page Numbers: 1460-7

Journal Abbreviation: Cell Cycle

ISSN: 1551-4005

DAY: 17

MONTH: 05

YEAR: 2007

Initiating the uninitiated: replication of damaged DNA and carcinogenesis. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pathology and Laboratory Medicine, Center for Environmental Health and Susceptibility, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599-7295, USA. wkarlk@med.unc.edu

Country: United States

AGENCY: United States NIEHS

GRANT: P30-ES10126

ACRONYM: ES

MEDLINETA: Cell Cycle

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