Inhibitory spectrum of mouse contrapsin and alpha-1-antitrypsin against mouse serine proteases.

Inhibitory spectrum of mouse contrapsin and alpha-1-antitrypsin against mouse serine proteases. Research Abstract Details 

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Inhibitory spectrum of mouse contrapsin and alpha-1-antitrypsin against mouse serine proteases. Abstract Text:

H Takahara,H Sinohara,

Contrapsin and alpha-1-antitrypsin have been recently characterized as major protease inhibitors in mouse plasma (Takahara, H. & Sinohara, H. (1982) J. Biol. Chem. 257, 2438-2446). We have studied the effects of the two inhibitors upon various serine proteases prepared from mouse tissues. Trypsin, plasmin and trypsin-like proteases of the submaxillary gland were inhibited by contrapsin but not by alpha-1-antitrypsin. On the other hand, chymotrypsin, elastase, and thrombin were inactivated by alpha-1-antitrypsin but not by contrapsin. Thus, their inhibitory spectra did not overlap each other in spite of their broad specificities. The inhibition of trypsin, chymotrypsin, and elastase was rapid and stoichiometric, whereas the inhibition of the other proteases was relatively slow. Contrapsin accounted for almost the total capacities of mouse plasma to inhibit both trypsin and submaxillary gland trypsin-like proteases, whereas alpha-1-antitrypsin was responsible for nearly all the capacities of plasma to inhibit both chymotrypsin and elastase.

Inhibitory spectrum of mouse contrapsin and alpha-1-antitrypsin against mouse serine proteases. Publishing Authors By Initials

H Takahara,H Sinohara,

For similar peptides: proteinase inhibitory proteins, secretory: alpha 1-antitrypsin research abstracts see: peptides: proteinase inhibitory proteins, secretory: alpha 1-antitrypsin research

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Inhibitory spectrum of mouse contrapsin and alpha-1-antitrypsin against mouse serine proteases. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 93

Page Numbers: 1411-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: May

YEAR: 1983

Inhibitory spectrum of mouse contrapsin and alpha-1-antitrypsin against mouse serine proteases. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Inhibitory spectrum of mouse contrapsin and alpha-1-antitrypsin against mouse serine proteases. Keywords Mesh Terms:

KEYWORDS: alpha 1-Antitrypsin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Inhibitory spectrum of mouse contrapsin and alpha-1-antitrypsin against mouse serine proteases. Information

Substance Name: Plasmin

Registry Number: EC 3.4.21.7

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Country: JAPAN

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MEDLINETA: J Biochem

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