Inhibitory effects of human and bovine milk constituents on rotavirus infections.

Inhibitory effects of human and bovine milk constituents on rotavirus infections. Research Abstract Details 

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Inhibitory effects of human and bovine milk constituents on rotavirus infections. Abstract Text:

A S Kvistgaard,L T Pallesen,C F Arias,S ,T E Petersen,C W Heegaard,J T Rasmussen,

Among etiologic agents, rotavirus is the major cause of severe dehydration diarrhea in infant mammals. In vitro and in vivo studies have indicated that the human milk-fat globule protein lactadherin inhibits rotavirus binding and protects breast-fed children against symptomatic rotavirus infection. The present work was conducted to evaluate the effect of lactadherin, along with some other milk proteins and fractions, on rotavirus infections in MA104 and Caco-2 cell lines. It is shown that human, and not bovine, lactadherin inhibits Wa rotavirus infection in vitro. Human lactadherin seems to act through a mechanism involving protein-virus interactions. The reason for the activity of human lactadherin is not clear, but it might lie within differences in the protein structure or the attached oligosaccharides. Likewise, in our hands, bovine lactoferrin did not show any suppressive activity against rotavirus. In contrast, MUC1 from bovine milk inhibits the neuraminidase-sensitive rotavirus RRV strain efficiently, whereas it has no effect on the neuraminidase-resistant Wa strain. Finally, a bovine macromolecular whey protein fraction turned out to have an efficient and versatile inhibitory activity against rotavirus.

Inhibitory effects of human and bovine milk constituents on rotavirus infections. Publishing Authors By Initials

AS Kvistgaard,LT Pallesen,CF Arias,S ,TE Petersen,CW Heegaard,JT Rasmussen,

For similar virus diseases: rna virus infections: reoviridae infections: rotavirus infections research abstracts see: virus diseases: rna virus infections: reoviridae infections: rotavirus infections research

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Inhibitory effects of human and bovine milk constituents on rotavirus infections. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of dairy science

VOLUME: 87

Page Numbers: 4088-96

Journal Abbreviation: J. Dairy Sci.

ISSN: 0022-0302

DAY: 1

MONTH: Dec

YEAR: 2004

Inhibitory effects of human and bovine milk constituents on rotavirus infections. Information

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LANGUAGE: eng

NlmUniqueID: 2985126

Inhibitory effects of human and bovine milk constituents on rotavirus infections. Keywords Mesh Terms:

KEYWORDS: Rotavirus Infections

MESH TERMS: prevention & control

Chemical & Substance for Abstract: Inhibitory effects of human and bovine milk constituents on rotavirus infections. Information

Substance Name: Peptide Fragments

Registry Number: 0

Grant and Affiliation Information for Inhibitory effects of human and bovine milk constituents on rotavirus infections.

AFFILIATION: Protein Chemistry Laboratory, University of Aarhus, Denmark.

Country: United States

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MEDLINETA: J Dairy Sci

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