Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity.

Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Research Abstract Details 

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Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Abstract Text:

Tae Chul Moon,Zhejiu Quan,Jeongsoo Kim,Hyun Pyo Kim,Ichiro Kudo,Makodo Murakami,Haeil Park,Hyeun Wook Chang,Tae Chul Moon,Zhejiu Quan,Jeongsoo Kim,Hyun Pyo Kim,Ichiro Kudo,Makodo Murakami,Haeil Park,Hyeun Wook Chang,Tae Chul Moon,Zhejiu Quan,Jeongsoo Kim,Hyun Pyo Kim,Ichiro Kudo,Makodo Murakami,Haeil Park,Hyeun Wook Chang,

Several prototypes of C-C biflavones (a-f) were synthesized and evaluated their inhibitory activity against phospholipase A(2)s (PLA(2)s) activity. The synthetic C-C biflavones (a-f) showed rather different inhibitory activity against various PLA(2)s. Most synthetic C-C biflavonoids exhibited potent and broad inhibitory activity against various sPLA(2)s and cPLA(2) tested regardless of their structural array. In particular, of natural and synthetic biflavonoids tested, the synthetic C-C biflavonoid (d) only showed inhibitory activity against sPLA(2) X. None of the natural and synthetic biflavonoids tested showed inhibitory activity against sPLA(2) IB. Further chemical modification of these basic structures will be carried out in order to investigate the synthetic C-C biflavones which possess more selective inhibitory activity against isozymes of PLA(2).

Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Publishing Authors By Initials

TC Moon,Z Quan,J Kim,HP Kim,I Kudo,M Murakami,H Park,HW Chang,TC Moon,Z Quan,J Kim,HP Kim,I Kudo,M Murakami,H Park,HW Chang,TC Moon,Z Quan,J Kim,HP Kim,I Kudo,M Murakami,H Park,HW Chang,

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Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry

VOLUME: 15

Page Numbers: 7138-43

Journal Abbreviation: Bioorg. Med. Chem.

ISSN: 0968-0896

DAY: 22

MONTH: 08

YEAR: 2007

Inhibitory effect of synthetic C-C biflavones on various phospholipase A(2)s activity. Information

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LANGUAGE: eng

NlmUniqueID: 9413298

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AFFILIATION: College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Republic of Korea.

Country: England

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MEDLINETA: Bioorg Med Chem

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