Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats.

Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats. Research Abstract Details 

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Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats. Abstract Text:

Akiko Inagaki,Hirofumi Ichikawa,Takashi Sakata,Akiko Inagaki,Hirofumi Ichikawa,Takashi Sakata,

Microbial breakdown of carbohydrates in the large intestine mainly produces short-chain fatty acids (SCFA). SCFA stimulate epithelial cell proliferation of the digestive tract in vivo. Succinic acid sometimes accumulates in the colonic lumen. However, the effect of succinic acid on colonic epithelial cell proliferation is unknown. Thus, we planned to clarify the influence of succinic acid on colonic epithelial cell proliferation in vivo. We continuously administered infusate with or without succinic acid (100 mM) into the distal colon of rats for 6 d and measured accumulated mitosis per crypt of distal colon of these rats. Succinic acid infused into rat colons significantly inhibited colonic cell proliferation and reduced crypt size. These results clearly indicated the inhibitory effects of succinic acid on colonic epithelial cell proliferation in vivo.

Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats. Publishing Authors By Initials

A Inagaki,H Ichikawa,T Sakata,A Inagaki,H Ichikawa,T Sakata,

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Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of nutritional science and vitaminology

VOLUME: 53

Page Numbers: 377-9

Journal Abbreviation: J. Nutr. Sci. Vitaminol.

ISSN: 0301-4800

DAY: 15

MONTH: Aug

YEAR: 2007

Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats.

AFFILIATION: School of Science and Engineering, Ishinomaki Senshu University, Ishinomaki, Japan.

Country: Japan

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MEDLINETA: J Nutr Sci Vitaminol (Tokyo)

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