[Inhibitory effect of grape procyanidin on the cell apoptosis induced by radiation]

[Inhibitory effect of grape procyanidin on the cell apoptosis induced by radiation] Research Abstract Details 

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[Inhibitory effect of grape procyanidin on the cell apoptosis induced by radiation] Abstract Text:

Hai-Zhen Liu,Jin-Yi Zhong,

OBJECTIVE: To study the inhibition effect of grape procyanidin (GPC) on the cell apoptosis and injury of proliferation induced by radiation. METHODS: Three indices including apoptosis rate, proliferation rate and expression of bcl-2 and bax protein were examined in the mice pancreas after taking different dose GPC by mouth and radiation by (60)Co-gamma ray once. RESULTS: The cell proliferation and bcl-2 expression in high dose GPC group (3.16% +/- 0.13% and 49.8% respectively), were higher than those in radiation control group (0.64% +/- 0.11%, 29.7%), but the cell apoptosis rate and bax expression (19.8% and 55.0% respectively), were lower than those in radiation control group (35.6%, 85.7%). All the above differences were statistically significant (P < 0.05). CONCLUSION: GPC has certain protective effect against the mice pancreatic cell apoptosis and the abnormal expression of bcl-2 and bax protein induced by (60)Co-gamma.

[Inhibitory effect of grape procyanidin on the cell apoptosis induced by radiation] Publishing Authors By Initials

HZ Liu,JY Zhong,

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[Inhibitory effect of grape procyanidin on the cell apoptosis induced by radiation] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Z

VOLUME: 22

Page Numbers: 448-51

Journal Abbreviation: Zhonghua Lao Dong Wei Sheng Zh

ISSN: 1001-9391

DAY: 7

MONTH: Dec

YEAR: 2004

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LANGUAGE: chi

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AFFILIATION: Weifang People's Hospital, Weifang, Shandong Province 261041, China.

Country: China

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MEDLINETA: Zhonghua Lao Dong Wei Sheng Zh

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