Inhibitory effect of gamma interferon on BK virus gene expression and replication.

Inhibitory effect of gamma interferon on BK virus gene expression and replication. Research Abstract Details 

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Inhibitory effect of gamma interferon on BK virus gene expression and replication. Abstract Text:

Johanna R Abend,Jonathan A Low,Michael J Imperiale,

BK virus (BKV) is widely accepted to be the causative agent of polyomavirus nephropathy. In immunocompromised individuals, especially kidney transplant recipients, BKV can replicate in kidney epithelial cells, causing loss of renal function and eventual destruction of the graft. Advances in immunosuppressive therapies may be partially responsible for the increasing incidence of polyomavirus nephropathy among transplant recipients by more effectively eliminating components of the immune system, such as gamma interferon (IFN-gamma)-producing lymphocytes, that keep BKV infections at a subclinical level. In this study, we investigated the role of IFN-gamma in regulating lytic infection by BKV. Treatment with IFN-gamma inhibited the expression of the viral early protein large tumor antigen (TAg) and the late protein VP1 in a dose-dependent manner. We detected 1.6- and 12-fold reductions in TAg transcripts at 48 and 96 h postinfection, respectively, with 250 U/ml IFN-gamma, suggesting that IFN-gamma-mediated inhibition occurs at the level of transcription. Furthermore, IFN-gamma inhibited the level of viral progeny production as much as 50-fold at a multiplicity of infection (MOI) of 0.5 and 80-fold at an MOI of 0.1. The inhibitory effects of IFN-gamma were similar for three different strains of BKV examined. These results indicate an important role for IFN-gamma in regulating BKV lytic infection.

Inhibitory effect of gamma interferon on BK virus gene expression and replication. Publishing Authors By Initials

JR Abend,JA Low,MJ Imperiale,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: viral physiology: virus replication research

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MEDLINE DATE:

Inhibitory effect of gamma interferon on BK virus gene expression and replication. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of virology

VOLUME: 81

Page Numbers: 272-9

Journal Abbreviation: J. Virol.

ISSN: 0022-538X

DAY: 11

MONTH: 10

YEAR: 2006

Inhibitory effect of gamma interferon on BK virus gene expression and replication. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 113724

Inhibitory effect of gamma interferon on BK virus gene expression and replication. Keywords Mesh Terms:

KEYWORDS: Virus Replication

MESH TERMS: drug effects

Chemical & Substance for Abstract: Inhibitory effect of gamma interferon on BK virus gene expression and replication. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Inhibitory effect of gamma interferon on BK virus gene expression and replication.

AFFILIATION: University of Michigan Medical School, 1500 East Medical Center Drive, 6304 Cancer Center, Ann Arbor, MI 48109-0942, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: T32-GM07544

ACRONYM: GM

MEDLINETA: J Virol

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