Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts.

Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts. Abstract Text:

Mingchang Zhang,Fang Bian,Chenting Wen,Nian Hao,

In order to investigate the effect of curcumin on proliferation and apoptosis of human pterygium fibroblasts (HPF) in culture and search for a new method to prevent the recurrence after pterygium surgery, HPF was incubated with 0-160 micromol/L curcumin for 24-96 h. The MTT method was used to assay the biologic activities of curcumin at different time points and different doses. The expression of proliferating cell nuclear antigen (PCNA) in each group was detected by immunohistochemistry. The cell cycle distribution was detected by flow cytometry (FCM). Administration of 20-80 micromol/L curcumin for 24-72 h could significantly inhibit HPF proliferation in a dose-and time-dependent manner (P<0.05). After treatment with curcumin at different concentrations of 20, 40, 80 and 160 micromol/L for 24 h, FCM revealed there was a significant sub-G1 peak at each concentration. The number of HPF in G0/G1 phase was increased, while in S phase, it was decreased (P<0.05). At the concentration of 20-80 micromol/L, curcumin, in a dose-dependent manner (P<0.05), could inhibit the expression of PCNA in HPF. It was suggested that curcumin could significantly inhibit the proliferation of HPF, make HPF arrest in G0/G1 phase and induce the apoptosis of HPF in a dose-and time-dependent manner.

Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts. Publishing Authors By Initials

M Zhang,F Bian,C Wen,N Hao,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 27

Page Numbers: 339-42

Journal Abbreviation: J. Huazhong Univ. Sci. Technol

ISSN: 1672-0733

DAY: 20

MONTH: Jun

YEAR: 2007

Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101169627

Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts.

AFFILIATION: Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. mingchangzhang@hotmail.com

Country: China

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Huazhong Univ Sci Technolog

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Inhibitory effect of curcumin on proliferation of human pterygium fibroblasts Related Publications

• A study of Dr. Gao Huiyuan's new prescriptions.
• Normative standards for vocal tract dimensions by race as measured by acoustic pharyngometry.
• Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.
• [A morphological study of chondrogenesis by adipose-derived adult stem cells induced by recombinant human bone morphogenetic protein 2]
• [Age-related changes of the function and amount of natural killer cells in the liver: experiment with mice]
• [Building artificial neural networks model on portable NIR integrity wheat component measuring apparatus]
• [Chemical constituents from Viscum nudum and their accelerating PC12 cell differentiation]
• [Clinical analysis of the infection with human papillomavirus in women]
• [Clinical and laboratory study of a case of hematidrosis]
• [Coronary artery bypass graft for patients with ascending aorta atherosclerosis]
• [Detection of the gene-deleted female carriers of Duchenne/Becker muscular dystrophy using a fluorescent in situ hybridization based method]
• [Dislocation of intraocular lens inferior loop and ciliochoroidal detachment caused by blunt contusion: a report of two cases]
• [Evaluation study on determination of ZPP in blood with hematofluorometer]
• [Helical structure revealed upon the beta heterochromatin of polytene chromosome of Drosophila virilis]
• [Improving the alertness of large granular lymphocytic leukemia]
• [Influence of transfected EGFR-cDNA on bcl-2 and Bax in glioblastoma cells]
• [Intergeneric somatic hybridization between Astragalus adsurgens Pall and Medicago sativa L.]
• [Long-term results of prosthetic mitral valve replacement with home-made tilting disc valve: a report of 125 cases]
• [Morphological and anatomical characterization of a stripe mutant with abnormal floral organs in rice]
• [Preparation and properties of complex of europium lanthanum with crown ether and p-phthalic acid]
• [Prospective randomized trial of prophylaxis of postoperative peritoneal carcinomatosis of advanced gastric cancer: intraperitoneal chemotherapy with mitomycin C bound to activated carbon particles]
• [Study of gene expression profiling in breast cancer by DNA microarray]
• [Study on large-scale CD34+ cell enrichment using immunomagnetic isolation apparatus]
• [Study on the distribution of vitamin D receptor gene start codon polymorphism in the Achangs and Hans]
• [Study on the seroepidemiology of Rickettsia infection in Henan province, 2004]
• [The expression of EST and ER in hemangioma with its clinical value]
• [The influence of KCl on SERS of fuchsin basic in silver colloids]
• [Two new flavones from Fordia cauliflora of Yunnan]
• [Ultrastructural localization of transcription sites of rRNA genes in the nucleolus of wheat]
• [Virological and clinical features of patients with sporadic hepatitis C]