Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation.

Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation. Research Abstract Details 

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Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation. Abstract Text:

Piyanart Sommani,Kouhei Yamashita,Takashi Miyoshi,Hiroko Tsunemine,Tsutomu Kodaki,Hiroko Mori,Kiichi Hirota,Toshiyuki Arai,Masataka Sasada,Keisuke Makino,Piyanart Sommani,Kouhei Yamashita,Takashi Miyoshi,Hiroko Tsunemine,Tsutomu Kodaki,Hiroko Mori,Kiichi Hirota,Toshiyuki Arai,Masataka Sasada,Keisuke Makino,

Hypoxia-inducible factor-1 (HIF-1) is a main regulator of metabolic adaptation to hypoxia. HIF-1alpha is induced by hypoxia, or by hypoxia-mimicking reagents, such as desferrioxamine (DFX), under a normoxic condition. A xanthine oxidase inhibitor, 6-formylpterin (6FP), is reported to exert its functions on reactive oxygen species (ROS) modulation. In this study, we investigated the effect of 6FP on HIF-1alpha expression under a DFX-treated or hypoxic condition. 6FP decreased HIF-1alpha expression at the protein level, but not at the mRNA level, in a dose-dependent manner, and this suppressive effect was reversed by the antioxidant, N-acetyl-L-cysteine (NAC). Furthermore, the ROS generated by 6FP was reversed with NAC coincubation. These findings suggest that intracellular ROS generated by 6FP decreased the HIF-1alpha protein accumulation under a DFX-treated or hypoxic condition.

Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation. Publishing Authors By Initials

P Sommani,K Yamashita,T Miyoshi,H Tsunemine,T Kodaki,H Mori,K Hirota,T Arai,M Sasada,K Makino,P Sommani,K Yamashita,T Miyoshi,H Tsunemine,T Kodaki,H Mori,K Hirota,T Arai,M Sasada,K Makino,

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Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biological & pharmaceutical bulletin

VOLUME: 30

Page Numbers: 2181-4

Journal Abbreviation: Biol. Pharm. Bull.

ISSN: 0918-6158

DAY: 5

MONTH: Nov

YEAR: 2007

Inhibitory effect of 6-formylpterin on HIF-1alpha protein accumulation. Information

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LANGUAGE: eng

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AFFILIATION: Institute of Advanced Energy, Kyoto University, Uji, Japan.

Country: Japan

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MEDLINETA: Biol Pharm Bull

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