Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks.

Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks. Research Abstract Details 

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Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks. Abstract Text:

Rajesh K Kana,Timothy A Keller,Nancy J Minshew,Marcel Adam Just,

BACKGROUND: Inhibiting prepotent responses is critical to optimal cognitive and behavioral function across many domains. Several behavioral studies have investigated response inhibition in autism, and the findings varied according to the components involved in inhibition. There has been only one published functional magnetic resonance imaging (fMRI) study so far on inhibition in autism, which found greater activation in participants with autism than control participants. METHODS: This study investigated the neural basis of response inhibition in 12 high-functioning adults with autism and 12 age- and intelligence quotient (IQ)-matched control participants during a simple response inhibition task and an inhibition task involving working memory. RESULTS: In both inhibition tasks, the participants with autism showed less brain activation than control participants in areas often found to be active in response inhibition tasks, namely the anterior cingulate cortex. In the more demanding inhibition condition, involving working memory, the participants with autism showed more activation than control participants in the premotor areas. In addition to the activation differences, the participants with autism showed lower levels of synchronization between the inhibition network (anterior cingulate gyrus, middle cingulate gyrus, and insula) and the right middle and inferior frontal and right inferior parietal regions. CONCLUSIONS: The results indicate that the inhibition circuitry in the autism group is activated atypically and is less synchronized, leaving inhibition to be accomplished by strategic control rather than automatically. At the behavioral level, there was no difference between the groups.

Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks. Publishing Authors By Initials

RK Kana,TA Keller,NJ Minshew,MA Just,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biological psychiatry

VOLUME: 62

Page Numbers: 198-206

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 29

MONTH: 11

YEAR: 2006

Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: physiopathology

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Grant and Affiliation Information for Inhibitory control in high-functioning autism: decreased activation and underconnectivity in inhibition networks.

AFFILIATION: Center for Cognitive Brain Imaging, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD35469

ACRONYM: HD

MEDLINETA: Biol Psychiatry

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