Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase.

Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase. Research Abstract Details 

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Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase. Abstract Text:

Nobuhiro Aburai,Yasuaki Esumi,Hiroyuki Koshino,Naoyuki Nishizawa,Ken-ichi Kimura,Nobuhiro Aburai,Yasuaki Esumi,Hiroyuki Koshino,Naoyuki Nishizawa,Ken-ichi Kimura,

Linoleic acid was isolated from both the methanol extracts of proso and Japanese millet as a histone deacetylase inhibitor. It showed uncompetitive inhibitory activity toward histone deacetylase (IC(50)=0.51 mM) and potent cytotoxicity toward human leukemia K562 (IC(50)=68 microM) and prostate cancer LNCaP cells (IC(50)=193 microM). Millet containing linoleic acid might have anti-tumor activity.

Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase. Publishing Authors By Initials

N Aburai,Y Esumi,H Koshino,N Nishizawa,K Kimura,N Aburai,Y Esumi,H Koshino,N Nishizawa,K Kimura,

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Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioscience, biotechnology, and biochemistry

VOLUME: 71

Page Numbers: 2061-4

Journal Abbreviation: Biosci. Biotechnol. Biochem.

ISSN: 0916-8451

DAY: 7

MONTH: 08

YEAR: 2007

Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase. Information

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LANGUAGE: eng

NlmUniqueID: 9205717

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Grant and Affiliation Information for Inhibitory activity of linoleic acid isolated from proso and Japanese millet toward histone deacetylase.

AFFILIATION: Department of Agro-Bioscience, Faculty of Agriculture, Iwate University, Morioka, Japan.

Country: Japan

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MEDLINETA: Biosci Biotechnol Biochem

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