Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.

Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Research Abstract Details 

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Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Abstract Text:

Ilya Lebeau,Graciela Andrei,Marcela ,Erik De Clercq,Antonin Holy,Robert Snoeck,

Murine polyomavirus and simian virus 40 were used to evaluate the potencies of the compounds of three classes of acyclic nucleoside phosphonates: (i) the original HPMP (3-hydroxy-2-phosphonomethoxypropyl) and PME (2-phosphonomethoxyethyl) derivatives, (ii) the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidine (DAPy) derivatives, and (iii) a new class of HPMP derivatives containing a 5-azacytosine moiety. The last class showed the highest activities and selectivities against both polyomaviruses.

Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Publishing Authors By Initials

I Lebeau,G Andrei,M ,E De Clercq,A Holy,R Snoeck,

For similar viruses: dna viruses: polyomaviridae: polyomavirus: simian virus 40 research abstracts see: viruses: dna viruses: polyomaviridae: polyomavirus: simian virus 40 research

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Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Antimicrobial agents and chemotherapy

VOLUME: 51

Page Numbers: 2268-73

Journal Abbreviation: Antimicrob. Agents Chemother.

ISSN: 0066-4804

DAY: 9

MONTH: 04

YEAR: 2007

Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Information

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LANGUAGE: eng

NlmUniqueID: 315061

Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Keywords Mesh Terms:

KEYWORDS: Simian virus 40

MESH TERMS: drug effects

Chemical & Substance for Abstract: Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains. Information

Substance Name: Cytosine

Registry Number: 71-30-7

Grant and Affiliation Information for Inhibitory activities of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate simian virus 40 strains.

AFFILIATION: Rega Institute for Medical Research, K.U. Leuven, Minderbroedersstraat 10, Leuven, Belgium.

Country: United States

AGENCY: United States NIAID

GRANT: AI 062540-01

ACRONYM: AI

MEDLINETA: Antimicrob Agents Chemother

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