Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid.

Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid. Research Abstract Details 

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Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid. Abstract Text:

M Tagaya,N Henomatsu,T Yoshimori,A Yamamoto,Y Tashiro,S Mizushima,

Nordihydroguaiaretic acid (NDGA) blocks intra-Golgi protein transport in a cell-free system and prolactin secretion from GH3 cells [Tagaya, M., Henomatsu, N., Yoshimori, T., Yamamoto, A., Tashiro, Y., and Fukui, T. (1993) FEBS Lett. 324, 201-204]. To determine which intracellular secretory pathway(s) is inhibited by NDGA, we investigated its effect on the transport of the vesicular stomatitis virus-encoded glycoprotein in BHK-21 cells. NDGA blocked protein transport from the endoplasmic reticulum to the Golgi apparatus, and from the trans-Golgi network to the plasma membrane. In addition, it retarded the brefeldin A-induced retrograde transport of mannosidase II to the endoplasmic reticulum. Although NDGA had an inhibitory effect on protein synthesis, it induced the expression of BiP, a chaperone located in the endoplasmic reticulum. The induction of BiP may be a consequence of the inhibition of protein transport by NDGA.

Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid. Publishing Authors By Initials

M Tagaya,N Henomatsu,T Yoshimori,A Yamamoto,Y Tashiro,S Mizushima,

For similar proteins: viral proteins: viral structural proteins: viral envelope proteins research abstracts see: proteins: viral proteins: viral structural proteins: viral envelope proteins research

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Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 119

Page Numbers: 863-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: May

YEAR: 1996

Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376600

Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid. Keywords Mesh Terms:

KEYWORDS: Viral Envelope Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid. Information

Substance Name: mannosyl-oligosaccharide 1,3 - 1,6-alpha

Registry Number: EC 3.2.1.114

Grant and Affiliation Information for Inhibition of vesicle-mediated protein transport by nordihydroguaiaretic acid.

AFFILIATION: School of Life Science, Tokyo University of Pharmacy and Life Science.

Country: JAPAN

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MEDLINETA: J Biochem

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