Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil.

Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil. Research Abstract Details 

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Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil. Abstract Text:

Mousumi Bose,Xingpei Hao,Jihyeung Ju,Ali Husain,Sunny Park,Joshua D Lambert,Chung S Yang,Mousumi Bose,Xingpei Hao,Jihyeung Ju,Ali Husain,Sunny Park,Joshua D Lambert,Chung S Yang,

The effect of a combination of (-)-epigallocatechin-3-gallate (EGCG) with fish oil on intestinal tumorigenesis in Apc (Min/+) mice fed a high-fat diet was investigated in the present study. The combined treatment of EGCG and fish oil for 9 weeks reduced the tumor number by 53% as compared to controls while neither agent alone had a significant effect. Apoptosis was significantly increased in all treatment groups. beta-Catenin nuclear positivity in adenomas from the combination group was lower than control mice, implicating the modulation of Wnt signaling by the combination. Fish oil and the combination significantly reduced prostaglandin E 2 (PGE 2) levels in small intestinal tumors as compared to controls, suggesting modulation of aberrant arachidonic acid metabolism by fish oil. Akt phosphorylation in adenomas was significantly reduced in all treatment groups, which may have contributed to the observed increase in apoptosis. The results indicate that a combination of low doses of EGCG and fish oil can inhibit tumor multiplicity in Apc (Min/+) mice.

Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil. Publishing Authors By Initials

M Bose,X Hao,J Ju,A Husain,S Park,JD Lambert,CS Yang,M Bose,X Hao,J Ju,A Husain,S Park,JD Lambert,CS Yang,

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Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of agricultural and food chemistry

VOLUME: 55

Page Numbers: 7695-700

Journal Abbreviation: J. Agric. Food Chem.

ISSN: 0021-8561

DAY: 16

MONTH: 08

YEAR: 2007

Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil. Information

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LANGUAGE: eng

NlmUniqueID: 374755

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Grant and Affiliation Information for Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil.

AFFILIATION: Susan L. Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, State University of New Jersey, 164 Frelinghuysen Road, Piscataway, New Jersey 08854-8020, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA88961

ACRONYM: CA

MEDLINETA: J Agric Food Chem

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