Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice.

Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice. Research Abstract Details 

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Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice. Abstract Text:

H Hua,Y Wang,C Wan,Y Liu,B Zhu,X Wang,Z Wang,J M Ding,

Biological clocks are intrinsic time-keeping systems that regulate behavior and physiological functions in most living organisms. Previous works suggested a possible link between the endogenous circadian clock and cell cycle regulation. The mammalian Period-2 gene (mPer2), an important component of the circadian clock mechanism, is recently demonstrated to play an important role in repressing tumor growth. In this study, we found that polyethylenimine-mediated intratumoral Per2 gene delivery had significant antitumor effects in C57BL/6 mice transplanted with Lewis lung carcinoma. Our data illustrated that the Per2 gene delivery inhibited PCNA expression and induced apoptosis. Our results support the emerging role of the circadian clock in critical aspects of tumorigenesis. These findings underscore the potential use of Per2 gene delivery as a novel therapeutic intervention for the treatment of malignant tumors.

Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice. Publishing Authors By Initials

H Hua,Y Wang,C Wan,Y Liu,B Zhu,X Wang,Z Wang,JM Ding,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer gene therapy

VOLUME: 14

Page Numbers: 815-8

Journal Abbreviation: Cancer Gene Ther.

ISSN: 0929-1903

DAY: 22

MONTH: 06

YEAR: 2007

Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice. Information

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LANGUAGE: eng

NlmUniqueID: 9432230

Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Inhibition of tumorigenesis by intratumoral delivery of the circadian gene mPer2 in C57BL/6 mice.

AFFILIATION: Laboratory of Molecular Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Country: England

AGENCY: United States NINDS

GRANT: NS047014

ACRONYM: NS

MEDLINETA: Cancer Gene Ther

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