Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets.

Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. Abstract Text:

Lena M Furci,Pedro Lopes,Suntara Eakanunkul,Shijun Zhong,Alexander D MacKerell,Angela Wilks,

The final step in heme utilization and iron acquisition in many pathogens is the oxidative cleavage of heme by heme oxygenase (HO), yielding iron, biliverdin, and carbon monoxide. Thus, the essential requirement for iron suggests that HO may provide a potential therapeutic target for antimicrobial drug development. Computer-aided drug design (CADD) combined with experimental assays identified small-molecule inhibitors of the Neisseria meningitidis HO (nm-HO). CADD virtual screening applied to 800 000 compounds identified 153 for biological assay. Several of the compounds were shown to have KD values in the micromolar range for nm-HO and the Pseudomonas aeruginosa HO (pa-HO). The compounds also inhibited the growth of P. aeruginosa as well as biliverdin formation in E. coli cells overexpressing nm-HO. Thus, CADD combined with experimental analysis has been used to identify novel inhibitors of the bacterial heme oxygenases that can cross the cell membrane and specifically inhibit HO activity.

Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. Publishing Authors By Initials

LM Furci,P Lopes,S Eakanunkul,S Zhong,AD MacKerell,A Wilks,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

PUBMED ID PMID:

MEDLINE DATE:

Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of medicinal chemistry

VOLUME: 50

Page Numbers: 3804-13

Journal Abbreviation: J. Med. Chem.

ISSN: 0022-2623

DAY: 13

MONTH: 07

YEAR: 2007

Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9716531

Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. Information

Substance Name: Heme Oxygenase (Decyclizing)

Registry Number: EC 1.14.99.3

Grant and Affiliation Information for Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets.

AFFILIATION: Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, 20 Penn Street, Baltimore, MD 21201-1140, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI 55912

ACRONYM: AI

MEDLINETA: J Med Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets Related Publications

• Adolescent view on risky and illegal alcohol use.
• Amoebiasis in Jamaica. A forgotten cause of hepato-intestinal disease.
• Anaemia in pregnancy associated with "big spleen disease".
• CHEMOPROPHYLAXIS OF HOMOZYGOUS SICKLERS WITH ANTIMALARIALS AND LONG-ACTING PENICILLIN.
• Catalytic turnover dependent modification of the Pseudomonas aeruginosa heme oxygenase (pa-HO) by 5,6-O-isopropyledine-2-O-allyl-ascorbic acid.
• Central myelinolysis in a patient with hyponatraemia.
• Characterization of the outer membrane receptor ShuA from the heme uptake system of Shigella dysenteriae. Substrate specificity and identification of the heme protein ligands.
• Collisional relaxation of superthermal electrons generated by relativistic laser pulses in dense plasma.
• Computer science. Is there progress on talking sensibly to machines?
• Drinking habits of central Queensland adolescents: local research for local needs.
• Effects of stochastic parametrization on conceptual climate models.
• Extending upon student drinking patterns in an Australian population.
• Functional characterization of the Shigella dysenteriae heme ABC transporter.
• Growth potential of radish in a controlled environment. SAM-TR-69-72.
• Heme inhibits the DNA binding properties of the cytoplasmic heme binding protein of Shigella dysenteriae (ShuS).
• High risk health behaviours among adult Jamaicans.
• Impact on blood pressure control of a six-month intervention project.
• Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets.
• International tourists, motor vehicles and road safety: a review of the literature leading up to the Sydney 2000 Olympics.
• MALARIAL ANTIBODIES IN IDIOPATHIC SPLENOMEGALY IN UGANDA.
• Motivational interviewing and cognitive behaviour therapy in the treatment of adolescent overweight and obesity: Study design and methodology.
• Profile of uncontrolled hypertensive patients attending the Specialist Hypertension Clinic, University Hospital of the West Indies.
• Psychometric evaluation of the shortened resilience scale among Alzheimer's caregivers.
• RAPID METHOD FOR URINARY PROTEIN CONCENTRATION. APPEARANCE OF MALARIA ANTIBODIES IN NEPHROTIC URINES.
• Serial electroencephalograms in a patient with D-lactic acidosis.
• Six-month hypertension intervention study. One year follow-up.
• Sliding wear studies of selected nitride coatings and their potential for long-term use in orthopaedic applications.
• The expression of antisense vascular endothelial growth factor (VEGF) sequences inhibits intracranial C6 glioma growth in vivo by suppressing tumour angiogenesis.
• The sleepless child.
• The use of herbal teas and remedies in Jamaica.