Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations.

Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations. Abstract Text:

Shin-Ichiro Masunaga,Kenji Nagata,Minoru Suzuki,Genro Kashino,Yuko Kinashi,Koji Ono,Shin-Ichiro Masunaga,Kenji Nagata,Minoru Suzuki,Genro Kashino,Yuko Kinashi,Koji Ono,

PURPOSE: We evaluated the usefulness of mild temperature hyperthermia (MTH) as an inhibitor of the repair of radiation-induced damage in terms of the responses of the total [= proliferating (P) + quiescent (Q)] and Q cell populations in solid tumors in vivo. MATERIALS AND METHODS: SCC VII tumor-bearing mice received a continuous administration of 5-bromo-2'-deoxyuridine (BrdU) to label all P cells. They then underwent high-dose-rate (HDR) gamma-ray irradiation immediately followed by MTH or administration of caffeine or wortmannin; alternatively, they underwent reduced-dose rate gamma-ray irradiation simultaneously with MTH or administration of caffeine or wortmannin. Nine hours after the start of irradiation, the tumor cells were isolated and incubated with a cytokinesis blocker, and the micronucleus (MN) frequency in cells without BrdU labeling (= Q cells) was determined using immunofluorescence staining for BrdU. The MN frequency in the total tumor cell population was determined using tumors that were not pretreated with BrdU. RESULTS: In both the total and Q-cell populations, especially the latter, MTH efficiently suppressed the reduction in sensitivity caused by leaving an interval between HDR irradiation and the assay and decreasing the irradiation dose rate, as well as the combination with wortmannin administration. CONCLUSION: From the viewpoint of solid tumor control as a whole, including intratumor Q-cell control, MTH is useful for suppressing the repair of both potentially lethal and sublethal damage.

Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations. Publishing Authors By Initials

S Masunaga,K Nagata,M Suzuki,G Kashino,Y Kinashi,K Ono,S Masunaga,K Nagata,M Suzuki,G Kashino,Y Kinashi,K Ono,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Radiation medicine

VOLUME: 25

Page Numbers: 417-25

Journal Abbreviation:

ISSN: 0288-2043

DAY: 26

MONTH: 10

YEAR: 2007

Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8412264

Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations.

AFFILIATION: Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, 2-1010 Asashiro-Nishi, Sennan-Gun, Osaka, Japan. smasuna@rri.kyoto-u.ac.jp

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Radiat Med

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations Related Publications

• A preliminary experimental study of boron neutron capture therapy for malignant tumors spreading in thoracic cavity.
• An Improved QT Interval Measurement based on Singular Value Decomposition.
• Autosomal loci associated with a sex-related difference in the development of autoimmune phenotypes in a lupus model.
• Browning of furfural and amino acids, and a novel yellow compound, furpipate, formed from lysine and furfural.
• Chromatin fine structure of the c-MYC insulator element/DNase I-hypersensitive site I is not preserved during mitosis.
• Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population.
• Dietary pulverized konjac glucomannan prevents the development of allergic rhinitis-like symptoms and IgE response in mice.
• Effect of components extracted from okara on the physicochemical properties of soymilk and tofu texture.
• Effect of gonadotropins, steroids and culture media on bovine oocyte maturation in vitro.
• Effects of culture systems on development of in vitro fertilized bovine ova into blastocysts.
• Effects of heparin dosage and sperm capacitation time on in vitro fertilization and cleavage of bovine oocytes matured in vitro.
• Effects of media and the presence of bovine oviduct epithelial cells during in vitro fertilization on fertilizability and developmental capacity of bovine oocytes.
• Effects of two treatments on semen from different bulls on in vitro fertilization results of bovine oocytes.
• First attempt of boron neutron capture therapy (BNCT) for hepatocellular carcinoma.
• Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis.
• Inhibition of repair of radiation-induced damage by mild temperature hyperthermia, referring to the effect on quiescent cell populations.
• Laparoscopic partial nephrectomy in upper-pole apical renal tumor using gauze sling and flexible laparoscope.
• Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics.
• Metal patterning on silicon surface by site-selective electroless deposition through colloidal crystal templating.
• Molecular and biochemical characterization of kettin in Caenorhabditis elegans.
• Nutritional enrichment of larval fish feed with thraustochytrid producing polyunsaturated fatty acids and xanthophylls.
• Paracoccidioidomycosis in wild monkeys from Paraná State, Brazil.
• Phosphatidylcholine could have a key role in the pathogenesis of steatohepatitis - Reply.
• Presenilin Is Involved In Maintaining Undifferentiated Myogenic Precursor Cells: 543: May 30 11:15 AM - 11:30 AM.
• Rapid-prototyped temporal bone and inner-ear models replicated by adjusting computed tomography thresholds.
• Representation of taste stimuli in the brain.
• T-wave Vector Alternans Detection based on Holter ECG Recordings.
• UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics.
• [Silent myocardial ischemia in children]
• [Skin changes of amyotrophic lateral sclerosis]