Inhibition of rat renin by antibody elicited against pure mouse renin and the effect on blood pressure.

Inhibition of rat renin by antibody elicited against pure mouse renin and the effect on blood pressure. Research Abstract Details 

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Inhibition of rat renin by antibody elicited against pure mouse renin and the effect on blood pressure. Abstract Text:

Antibodies raised against mouse submaxillary renin showed affinity for rat renal renin. The affinity was characterized by enzyme kinetics in vitro. The antibodies and the purified Fab fragments showed total inhibition of rat renin, with a Ki of 6.5 +/- 0.7 x 10(-8)mol/l for the Fab fragments. The effect of enzymatic inhibition on blood pressure in anaesthetized rats was compared with converting enzyme inhibition. The antibodies showed a significant effect on blood pressure, with a depressor effect corresponding to that of the converting enzyme inhibitor [SQ 20 881]. The reduction of mean arterial pressure was from 116 +/- 3 to 108 +/- 3 mmHg for the antibodies and to 107 +/- 4 mmHg for the converting enzyme inhibitor. The pressor response of infused rat renal renin was totally blocked by the antibodies while pressor responses of angiotensin II were unchanged.

Inhibition of rat renin by antibody elicited against pure mouse renin and the effect on blood pressure. Publishing Authors By Initials

For similar peptides: oligopeptides: teprotide research abstracts see: peptides: oligopeptides: teprotide research

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MEDLINE DATE:

Inhibition of rat renin by antibody elicited against pure mouse renin and the effect on blood pressure. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pathologica, microbiologica, et immunologica

VOLUME: 90

Page Numbers: 81-6

Journal Abbreviation:

ISSN: 0108-0202

DAY: 26

MONTH: Apr

YEAR: 1982

Inhibition of rat renin by antibody elicited against pure mouse renin and the effect on blood pressure. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8206624

Inhibition of rat renin by antibody elicited against pure mouse renin and the effect on blood pressure. Keywords Mesh Terms:

KEYWORDS: Teprotide

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Inhibition of rat renin by antibody elicited against pure mouse renin and the effect on blood pressure. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Inhibition of rat renin by antibody elicited against pure mouse renin and the effect on blood pressure.

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Country: DENMARK

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MEDLINETA: Acta Pathol Microbiol Immunol

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