Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge.

Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge. Abstract Text:

Jia-Ping Zhang,Xi Ying,Yu Chen,Zong-Cheng Yang,Yue-Sheng Huang,Jia-Ping Zhang,Xi Ying,Yu Chen,Zong-Cheng Yang,Yue-Sheng Huang,

This study was aimed to investigate the effects of SB203580, the specific p38 mitogen-activated protein (MAP) kinase inhibitor, on cardiac myocyte survival and secretion of cytokines in an in vitro model of hypoxia and burn serum challenge. Results demonstrated that hypoxia and burn serum induced a persistent activation of p38 MAP kinase in primary cultured neonatal rat cardiomyocytes during the 12h period of stimulation, concomitant with a time-dependent increased expression of tumor necrosis factor (TNF)-alpha and inducible nitric oxide (iNOS), a progressively developed oxidative stress reflected by malondialdehyde (MDA) production, and myocytes injury evidenced by the increased levels of released lactate dehydrogenase (LDH) and the decreased myocyte viability. Furthermore, hypoxia and burn serum resulted in a significant increase in myocyte apoptosis, which may account for the impairment of myocyte viability as observed. SB203580 abolished p38 MAP kinase activation, blunted the upregulation of TNF-alpha, iNOS and the subsequent nitric oxide (NO) production, reduced oxidative stress, and alleviated hypoxia and burn serum-induced myocytes injury or apoptosis. These results demonstrated for the first time that inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge possibly via reducing the production of cytokines, such as TNF-alpha and NO, and the subsequent oxidative stress, providing strong evidence that the excessive inflammatory cytokines produced by cardiomyocytes themselves may be sufficient to cause myocardial injury after burn.

Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge. Publishing Authors By Initials

JP Zhang,X Ying,Y Chen,ZC Yang,YS Huang,JP Zhang,X Ying,Y Chen,ZC Yang,YS Huang,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Burns : journal of the International Society for B

VOLUME: 34

Page Numbers: 220-7

Journal Abbreviation:

ISSN: 0305-4179

DAY: 10

MONTH: 08

YEAR: 2007

Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8913178

Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge.

AFFILIATION: State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burns, Southwest Hospital, Third Military Medical University, Chongqing 400038, China.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Burns

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge Related Publications

• Clinicopathological observation of renal adenomas.
• Effects of the central amygdaloid nucleus lesions on the gustatory responses in the parabrachial nucleus in rats.
• Ehlers-Danlos syndrome: case and pedigree report and review.
• Telangiectatic osteosarcoma: a clinicopathologic analysis of 14 cases.
• [A rapid and simple detection of DNA fragment with point mutation by capillary electrophoresis]
• [A simple and rapid new method for SNP typing by single-tube bi-directional allele specific amplification]
• [Algorithms of multiband remote sensing for coastal red tide waters]
• [Analysis of factors correlated to death and reinfarction in patients with acute myocardial infarction]
• [Application of liposuction in scar repair]
• [Biomechanical evaluation of the stability of General spine system]
• [Clinical analysis of combined resection for T4 gastric cancer: report of 69 cases]
• [Determination of residues of organic chloride pesticide in Chinese Medicinal materials with capillary gas chromatography]
• [Ecological characteristics of Prorocentrum dentatum and the cause of harmful algal bloom formation in China Sea]
• [Effect of intracerebroventricular injection of histamine on carotid sinus baroreceptor reflex in anesthetized rats and its mechanism]
• [Experience with cardioventer defibrillator therapy in 113 patients]
• [Lower back pain in truck drivers working in plateau areas and its prevention]
• [Mammographic findings of gynecomastia]
• [Miniature quadrupole mass spectrometer array and its applications in manned spaceflight]
• [Molecular identification of human/goat xenogeneic model]
• [Phosphorylated JNK mediated apoptosis induced by all trans retinoid acid in human retinoblastoma cell line]
• [Protective effects of c-jun anti-sense gene recombinant transfection on rat cardiomyocytes inflicted by hypoxia and burn serum]
• [Purification and stability studies of prokaryotic PDCD5 protein]
• [Rat heart transplantation immune tolerance induced by blockade of B7-CD28 interaction]
• [Repair of facial defect with expanded skin flap from medial upper arm]
• [Secondary reconstruction of post-fracture deformities in the nasal-orbital ethmoid region]
• [Study on morphological change in intestinal mucosa from injury to repair after hemorrhagic shock]
• [Study on the therapeutic effect of combined use of obidoxime and atropine with respiratory machine on respiratory muscle paralysis caused by omethoate poisoning of rats]
• [The correlations between glucocorticoid receptor of lymphocyte and immune function]
• [The reason and prevention of upper cervical reoperations]
• [The relation and evaluation of the vertebral artery and the nerve root to posterior lateral mass screw fixation]