Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage.

Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage. Research Abstract Details 

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Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage. Abstract Text:

Notch receptors are involved in directing the choice between alternative cell fates in developmental scenarios such as thymopoiesis. By pharmacological interference in rat fetal thymus organ culture we show that inhibition of Notch signaling arrests T cell development at an early double-negative stage and is accompanied by a dramatic increase in the number of NK cells. These cells show an activated phenotype, lack recombination of the TCR beta gene locus and express perforin. Similarly, in thymic lobes reconstituted with fetal liver cells, progenitors predominantly develop into NK cells both after pharmacological interference of Notch and after treatment with a recombinant rat Notch1/Fc chimera. Collectively, this identifies the lineage decision of NK/T precursor cells as an important site of Notch action in rat thymocytes.

Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage. Publishing Authors By Initials

For similar organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: butyric acids: aminobutyric acids: gamma-aminobutyric acid research

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Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: European journal of immunology

VOLUME: 34

Page Numbers: 1405-13

Journal Abbreviation: Eur. J. Immunol.

ISSN: 0014-2980

DAY: 5

MONTH: May

YEAR: 2004

Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage. Information

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LANGUAGE: eng

NlmUniqueID: 1273201

Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage. Keywords Mesh Terms:

KEYWORDS: gamma-Aminobutyric Acid

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage. Information

Substance Name: Endopeptidases

Registry Number: EC 3.4.-

Grant and Affiliation Information for Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage.

AFFILIATION: Institute of Virology and Immunobiology, University of Wuerzburg, Wuerzburg, Germany.

Country: Germany

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MEDLINETA: Eur J Immunol

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