Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA.

Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA. Abstract Text:

Shi-Zhong Zhang,Zhi-Guo Ye,Qiang Xia,Wei Zhang,Iain Bruce,

The objective of this study was to determine whether the mitochondrial permeability transition pore plays a role in cardioprotection induced by tanshinone IIA. Isolated rat hearts were subjected to 30 min regional ischemia by ligation of the left anterior descending artery followed by 120 min reperfusion. Ischemic preconditioning (IPC) was achieved by two 5-min periods of global ischemia separated by 5 min of reperfusion. Pretreatment with tanshinone reduced the infarct size which was associated with improved recovery of left ventricular contractility as with IPC. Perfusion with 100 muM 5-hydroxydecanoate (5-HD) attenuated the cardioprotection induced by tanshinone. In mitochondria isolated from untreated hearts, tanshinone inhibited pore opening dose-dependently, and this effect was abolished by blocking the mitochondrial ATP sensitive potassium channel with 5-HD. We conclude that pretreatment with tanshinone IIA provides similar cardioprotection to IPC, this effect may be via inhibiting the pore opening during reperfusion, and the mitochondrial ATP sensitive potassium channel may play a role in mediating the pore inhibition induced by tanshinone IIA.

Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA. Publishing Authors By Initials

SZ Zhang,ZG Ye,Q Xia,W Zhang,I Bruce,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 3

Page Numbers: 2276-9

Journal Abbreviation:

ISSN: 1557-170X

DAY: 6

MONTH: 02

YEAR: 2005

Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101243413

Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA.

AFFILIATION: Dept. of Physiol., Zhejiang Univ. Sch. of Med., Hangzhou.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Conf Proc IEEE Eng Med Biol So

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA Related Publications

• Are patient expectations still relevant for psychotherapy process and outcome?
• Diabetes, depression, and death: a randomized controlled trial of a depression treatment program for older adults based in primary care (PROSPECT).
• Digital Mammogram Spiculated Mass Detection and Spicule Segmentation using Level Sets.
• Digital Mammographic Computer Aided Diagnosis (CAD) using Adaptive Level Set Segmentation.
• Disasters, social forces, and opportunities.
• Endothelium-independent Vasorelaxant Effect of the Phyto-oestrogen Biochanin A on Rat Thoracic Aorta.
• Evaluation of low energy CID and ECD fragmentation behavior of mono-oxidized thio-ether bonds in peptides.
• Evaluation of respiratory muscles activity by means of cross mutual information function at different levels of ventilatory effort.
• Evidence for schema theory from surface electromyography: an artificial neural network approach.
• Exploring the biochemical properties and remediation applications of the unusual explosive-degrading P450 system XplA/B.
• Getting to the heart of cardiomyopathies.
• Healing by primary versus secondary intention after surgical treatment for pilonidal sinus.
• Improvement of Ventricular Mechanical Properties by Puerarin Involves Mitochondrial Permeability Transition in Isolated Rat Heart during Ischemia and Reperfusion.
• Inhibition of Mitochondrial Permeability Transition Pore: A Possible Mechanism for Cardioprotection Conferred by Pretreatment with Tanshinone IIA.
• Level set-based core segmentation of mammographic masses facilitating three stage (core, periphery, spiculation) analysis.
• Mass spectrometry identifiable cross-linking strategy for studying protein-protein interactions.
• Near IR-emitting DNA-probes exploiting stepwise energy transfer processes.
• Neurovascular complications following percutaneous tendoachillis tenotomy for congenital idiopathic clubfoot.
• Photoprotection in the lichen Parmelia sulcata: the origins of desiccation-induced fluorescence quenching.
• Role of preoperative arthrography in early Perthes disease as a decision-making tool. Is it really necessary?
• Social support and suicidal ideation in older adults using home healthcare services.
• Suicidal ideation among elderly homecare patients.
• Synthesis of asymmetrically substituted cyclen-based ligands for the controlled sensitisation of lanthanides.
• Targeting the brain: rationalizing the novel methods of drug delivery to the central nervous system.
• The effect of a primary care practice-based depression intervention on mortality in older adults: a randomized trial.
• The physical characteristics of materials used in the manufacture of orthoses for patients with diabetes.
• Transition to home care: quality of mental health, pharmacy, and medical history information.
• Treating late-life depression with interpersonal psychotherapy in the primary care sector.
• Urban poverty and infant mortality rate disparities.
• What is your diagnosis? Type 1 Monteggia fracture.