Inhibition of human ovarian tumor growth by cytokine-induced killer cells.

Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Research Abstract Details 

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Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Abstract Text:

Hwan Mook Kim,Jong Soon Kang,Jaeseung Lim,Song-Kyu Park,Kiho Lee,Yeo Dae Yoon,Chang Woo Lee,Ki Hoon Lee,Gyoonhee Han,Kyu-Hwan Yang,Yeon Jin Kim,Youngsoo Kim,Sang-Bae Han,Hwan Mook Kim,Jong Soon Kang,Jaeseung Lim,Song-Kyu Park,Kiho Lee,Yeo Dae Yoon,Chang Woo Lee,Ki Hoon Lee,Gyoonhee Han,Kyu-Hwan Yang,Yeon Jin Kim,Youngsoo Kim,Sang-Bae Han,Hwan Mook Kim,Jong Soon Kang,Jaeseung Lim,Song-Kyu Park,Kiho Lee,Yeo Dae Yoon,Chang Woo Lee,Ki Hoon Lee,Gyoonhee Han,Kyu-Hwan Yang,Yeon Jin Kim,Youngsoo Kim,Sang-Bae Han,

Despite the recent improvement in the treatment of ovarian cancer, this disease is still leading cause of cancer death in women. In this study, the anti-tumor activity of cytokine-induced killer (CIK) cells against human ovarian cancer was evaluated in vitro and in vivo. Although CD3+CD56+ cells were rare in fresh human peripheral blood mononuclear cells, they could expand more than 1,000-fold on day 14 in the presence of anti-CD3 antibody plus IL-2. At an effector-target cell ratio of 30:1, CIK cells destroyed 45% of SK-OV-3 human ovarian cancer cells, which was determined by the 51Cr-release assay. In addition, CIK cells at a dose of 23 million cells per mouse inhibited 73% of SK-OV-3 tumor growth in nude mouse xenograft assay. This study suggests that CIK cells may be used as an adoptive immunotherapy for patients with ovarian cancer.

Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Publishing Authors By Initials

HM Kim,JS Kang,J Lim,SK Park,K Lee,YD Yoon,CW Lee,KH Lee,G Han,KH Yang,YJ Kim,Y Kim,SB Han,HM Kim,JS Kang,J Lim,SK Park,K Lee,YD Yoon,CW Lee,KH Lee,G Han,KH Yang,YJ Kim,Y Kim,SB Han,HM Kim,JS Kang,J Lim,SK Park,K Lee,YD Yoon,CW Lee,KH Lee,G Han,KH Yang,YJ Kim,Y Kim,SB Han,

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Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of pharmacal research

VOLUME: 30

Page Numbers: 1464-70

Journal Abbreviation: Arch. Pharm. Res.

ISSN: 0253-6269

DAY: 19

MONTH: Nov

YEAR: 2007

Inhibition of human ovarian tumor growth by cytokine-induced killer cells. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Inhibition of human ovarian tumor growth by cytokine-induced killer cells.

AFFILIATION: Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Ochang, Chungbuk 363-883, Korea.

Country: Korea (South)

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MEDLINETA: Arch Pharm Res

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