Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration.

Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. Abstract Text:

Huan Chen,Shengsheng Yang,Zhifeng Yang,Li Ma,Dandan Jiang,Jifang Mao,Binghua Jiao,Zailong Cai,Huan Chen,Shengsheng Yang,Zhifeng Yang,Li Ma,Dandan Jiang,Jifang Mao,Binghua Jiao,Zailong Cai,

Serine-threonine protein kinase glycogen synthase kinase (GSK)-3 is involved in regulation of many cell functions, but its role in regulating liver regeneration is unknown. Here we investigated the effects of GSK-3beta inhibition on liver regeneration after partial hepatectomy in the rat. The potent and selective GSK-3beta inhibitor SB216763 (0.6 mg/kg intravenously) or vehicle (10% dimethyl sulfoxide) was administered 30 min before 70% partial hepatectomy. Liver regeneration was estimated by the cell proliferation, apoptosis, and the related cell signaling and cycling proteins. In 30 min after hepatectomy in the rat, GSK-3beta was found to be translocated to the nucleus, but GSK-3beta inhibitor SB216763 that could phosphorylate residue Ser9 on GSK-3beta did not attenuated the accumulation. Consequently, the inhibition of GSK-3beta decreased the nuclear factor-kappaB activity, the NF-kappaB-dependent gene expression, and COX2 expression, but enhanced p21(WAF1/Cip1) transcription. Moreover, the injection of SB216763 impaired the proliferation cell nuclear antigen (PCNA) index and increased the apoptosis of liver compared to the vehicle. GSK-3beta plays an important role in rat liver regeneration. We conclude it may partially result from the inhibition of the NF-kappaB pathway and enhancement of p21 (WAF1/Cip1) expression. J. Cell. Biochem. 102: 1281-1289, 2007. (c) 2007 Wiley-Liss, Inc.

Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. Publishing Authors By Initials

H Chen,S Yang,Z Yang,L Ma,D Jiang,J Mao,B Jiao,Z Cai,H Chen,S Yang,Z Yang,L Ma,D Jiang,J Mao,B Jiao,Z Cai,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cellular biochemistry

VOLUME: 102

Page Numbers: 1281-9

Journal Abbreviation: J. Cell. Biochem.

ISSN: 0730-2312

DAY: 1

MONTH: Dec

YEAR: 2007

Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8205768

Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration.

AFFILIATION: Clinical Research Center, Changhai Hospital, Shanghai 200433, China.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Cell Biochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration Related Publications

• Expression of vascular endothelial growth factor and E26 transformation-specific-1 in breast carcinoma.
• [A related analysis for alpha, beta fibrinogen gene haplotypes and nucleotide polymorphisms associated with the ischemic stroke in Hainan Han population]
• [Advances in researches on genes and their pathophysiological implications of schizophrenia]
• [Application of atomic force microscopy in cell biology]
• [Cytomegalovirus infection of myeloma cell line KM3 and its effect on IL-6 mRNA expression in the cells]
• [Detection of 8-hydroxyguanine in the DNA of the H2O2-treated HL-60 cells by GC/FID]
• [Determination of deoxyribonucleic acid with nitro-tetrazolium chloride blue by resonance light-scattering technique]
• [Determination of dimethyl ether correction factors in gas chromatography with TCD and FID]
• [Determination of liensinine in plasma by high performance liquid chromatography]
• [Determination of prostaglandinum E1 by fluorescence extinction method]
• [Determination of soluble heavy metal Pb, Cd and Cr in water based architectural coatings for indoor decorating and refurbishing materials by ICP-AES]
• [Distribution and germination of Alexandrium sp. cysts in coastal areas of Southeast China Sea]
• [Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells (HepG2)]
• [Effect of apoptosis induced by different vitamin E homologous analogues in human hepatoma cells(HepG2)]
• [Effect of different vitamin E homologous analogues on human hepatoma cell HepG2 proliferation in vitro]
• [Establishment of animal model for in vitro spermatogenesis by heterotopic grafting of neonatal mouse testis.]
• [Experimental study on repair of goat tibia defect with marrow stromal cell and bio-derived bone]
• [Gamma knife radiosurgery for hemangioblastomas: clinical results and pathological findings]
• [Generation of CD14+ dendritic cells in vitro with GM-CSF and IL-4]
• [Nitrogen and phosphorus absorption and growth characteristics of Alexandrium tamarense]
• [Perivascular epithelioid cell tumor (PEComa) of the uterine]
• [Progress in treatment of infantile spasms]
• [Relationship between the IFN-gamma producing cells specific for recipient and acute graft versus host disease]
• [Spectrophotometric studies on and applications of the reaction of copper with 2-hydroxy-3-carboxy-5-sulfobenzenediazoaminoazobenzene]
• [Study on the expressions of basic fibroblast growth factor and nervous growth factor genes in rat cerebral concussion]
• [Study on the level of environmental endocrine disruptors in serum of precocious puberty patients]
• [Surgical treatment of congenital anophthalmia]
• [The comparison between regenerated cortex and primary cortex of Cortex Cinnamomi on description and microscopic characters]
• [The therapeutic effect of early enteral nutrition togather with recombinant human growth hormone on severely scalded rats]
• [Value of lymph node micrometastasis detected by RT-PCR assay in determining the stage of gastric carcinoma]