Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis.

Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Research Abstract Details 

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Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Abstract Text:

Xiaoli Guo,Kazuaki Nakamura,Kuniko Kohyama,Chikako Harada,Heather A Behanna,D Martin Watterson,Yoh Matsumoto,Takayuki Harada,Xiaoli Guo,Kazuaki Nakamura,Kuniko Kohyama,Chikako Harada,Heather A Behanna,D Martin Watterson,Yoh Matsumoto,Takayuki Harada,

Activated microglia and astrocytes have been implicated in the course of multiple sclerosis (MS) and its animal model: experimental autoimmune encephalomyelitis (EAE). MW01-5-188WH is a novel drug that selectively inhibits glial activation in the central nervous system (CNS). We report here that MW01-5-188WH is effective to ameliorate the severity of myelin oligodendrocyte glycoprotein (MOG)-induced EAE. Daily oral administration of MW01-5-188WH at 5mg/kg body weight reduced the clinical scores of EAE mice while having no influence on the disease incidence or animal mortality. Pathological examination revealed reduced numbers of microglia and astrocytes in the spinal cord of MW01-5-188WH-treated EAE mice. Moreover, MW01-5-188WH suppressed the release of key chemokines, which are involved in MS pathology, from cultured microglia and astrocytes. Taken together, our results indicate that treatments that suppress the activation of microglia and astrocytes should be pursued in future research for their potential as avenues for the treatment of MS.

Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Publishing Authors By Initials

X Guo,K Nakamura,K Kohyama,C Harada,HA Behanna,DM Watterson,Y Matsumoto,T Harada,X Guo,K Nakamura,K Kohyama,C Harada,HA Behanna,DM Watterson,Y Matsumoto,T Harada,

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Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroscience research

VOLUME: 59

Page Numbers: 457-66

Journal Abbreviation: Neurosci. Res.

ISSN: 0168-0102

DAY: 30

MONTH: 08

YEAR: 2007

Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis.

AFFILIATION: Department of Molecular Neurobiology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu, Tokyo, Japan.

Country: Ireland

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MEDLINETA: Neurosci Res

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