Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion.

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Research Abstract Details 

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Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Abstract Text:

Jeffrey S Scehnet,Weidong Jiang,S Ram Kumar,Valery Krasnoperov,Alexandre Trindade,Rui Benedito,Dusan Djokovic,Cristina Borges,Eric J Ley,Antonio Duarte,Parkash S Gill,

Vascular development is dependent on various growth factors and certain modifiers critical for providing arterial or venous identity, interaction with the surrounding stroma and tissues, hierarchic network formation, and recruitment of pericytes. Notch receptors and ligands (Jagged and Delta-like) play a critical role in this process in addition to VEGF. Dll4 is one of the Notch ligands that regulates arterial specification and maturation events. In the current study, we have shown that loss of function by either targeted allele deletion or use of a soluble form of Dll4 extracellular domain leads to inhibition of Notch signaling, resulting in increased vascular proliferation but defective maturation. Newly forming vessels have thin caliber, a markedly reduced vessel lumen, markedly reduced pericyte recruitment, and deficient vascular perfusion. sDll4 similarly induced defective vascular response in tumor implants leading to reduced tumor growth. Interference with Dll4-Notch signaling may be particularly desirable in tumors that have highly induced Dll4-Notch pathway.

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Publishing Authors By Initials

JS Scehnet,W Jiang,SR Kumar,V Krasnoperov,A Trindade,R Benedito,D Djokovic,C Borges,EJ Ley,A Duarte,PS Gill,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Blood

VOLUME: 109

Page Numbers: 4753-60

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 20

MONTH: 02

YEAR: 2007

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: metabolism

Chemical & Substance for Abstract: Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion.

AFFILIATION: Department of Pathology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01 CA 079218-07

ACRONYM: CA

MEDLINETA: Blood

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