Inhibition of cyclin-dependent kinases - a review of the recent patent literature.

Inhibition of cyclin-dependent kinases - a review of the recent patent literature. Research Abstract Details 

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Inhibition of cyclin-dependent kinases - a review of the recent patent literature. Abstract Text:

Andrea D Basso,Ronald J Doll,Andrea D Basso,Ronald J Doll,Andrea D Basso,Ronald J Doll,

The cyclin dependent kinases, Cdks, are potential targets for new anticancer therapy. Dysregulation of the cell cycle is common during tumorigenesis, and inhibition of certain Cdks has been shown to inhibit tumor cell growth, induce apoptosis and cause tumor regressions in animal models. This review discusses the rationale for inhibiting Cdks as an approach to cancer therapy and the status of Cdk inhibitors in clinical trials. Compounds resulting from a patent literature search from 2003 to July, 2005 are discussed.

Inhibition of cyclin-dependent kinases - a review of the recent patent literature. Publishing Authors By Initials

AD Basso,RJ Doll,AD Basso,RJ Doll,AD Basso,RJ Doll,

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Inhibition of cyclin-dependent kinases - a review of the recent patent literature. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Recent patents on anti-cancer drug discovery

VOLUME: 1

Page Numbers: 357-67

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ISSN: 1574-8928

DAY: 28

MONTH: Nov

YEAR: 2006

Inhibition of cyclin-dependent kinases - a review of the recent patent literature. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Inhibition of cyclin-dependent kinases - a review of the recent patent literature.

AFFILIATION: Schering-Plough Research Institute, Department of Tumor Biology, Departmant of Chemical Research, 2015 Galloping Hill Road, Kenilworth, NJ 07033-1300, USA. ronald.doll@spcorp.com.

Country: United Arab Emirates

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MEDLINETA: Recent Patents Anticancer Drug

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