Inhibition of cyclin D1 gene transcription by Brg-1.

Inhibition of cyclin D1 gene transcription by Brg-1. Research Abstract Details 

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Inhibition of cyclin D1 gene transcription by Brg-1. Abstract Text:

Mahadev Rao,Mathew C Casimiro,Michael P Lisanti,Mark D'Amico,Chenguang Wang,L Andrew Shirley,Jennifer E Leader,Manran Liu,Michael Stallcup,Daniel A Engel,Daniel J Murphy,Richard G Pestell,

The evolutionarily conserved SWI-SNF chromatin remodeling complex regulates cellular proliferation. A catalytic subunit, BRG-1, is frequently down regulated, silenced or mutated in malignant cells, however, the mechanism by which BRG-1 may function as a tumor suppressor or block breast cancer cellular proliferation is not understood. The cyclin D1 gene is a collaborative oncogene overexpressed in greater than 50% of human breast cancers. Herein, BRG-1 inhibited DNA synthesis and cyclin D1 expression in human MCF-7 breast cancer epithelial cells. The cyclin D1 promoter AP-1 and CRE sites were required for repression by BRG-1 in promoter assays. BRG-1 deficient cells abolished and siRNA to BRG-1 reduced, formation of the BRG-1 chromatin complex. The endogenous cyclin D1 promoter AP-1 site bound BRG-1. Estradiol treatment of MCF-7 cells induced recruitment of BRG-1 to the endogenous hpS2 gene promoter. Estradiol, which induced cyclin D1 abundance, was associated with a reduction in recruitment of the co-repressors HP1alpha/HDAC1 to the endogenous cyclin D1 promoter AP-1/BRG-1 binding sites. These studies suggest the endogenous cyclin D1 promoter BRG-1 binding site functions as a molecular scaffold in the context of local chromatin upon which coactivators and corepressors are recruited to regulate cyclin D1.

Inhibition of cyclin D1 gene transcription by Brg-1. Publishing Authors By Initials

M Rao,MC Casimiro,MP Lisanti,M D'Amico,C Wang,LA Shirley,JE Leader,M Liu,M Stallcup,DA Engel,DJ Murphy,RG Pestell,

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Inhibition of cyclin D1 gene transcription by Brg-1. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Cell cycle (Georgetown, Tex.)

VOLUME: 7

Page Numbers: 647-55

Journal Abbreviation: Cell Cycle

ISSN: 1551-4005

DAY: 12

MONTH: 12

YEAR: 2007

Inhibition of cyclin D1 gene transcription by Brg-1. Information

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LANGUAGE: eng

NlmUniqueID: 101137841

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Grant and Affiliation Information for Inhibition of cyclin D1 gene transcription by Brg-1.

AFFILIATION: Kimmel Cancer Center, Department of Cancer Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.

Country: United States

AGENCY: United States NCI

GRANT: R01CA75503

ACRONYM: CA

MEDLINETA: Cell Cycle

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