Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++.

Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++. Abstract Text:

W Greil,G Niedernhuber,D Stübner,R Gärtner,

The mechanism of cAMP-inhibition by EGF was studied in isolated porcine thyroid follicles. EGF inhibited TSH-induced cAMP-formation maximally by 40%, this effect remained up to 1 h of pre-incubation. The calcium-ionophore A 23 187 also inhibited cAMP-formation, but its effect was relieved after 1 h. The phorbolester TPA had a biphasic influence on cAMP-formation, with a transient increase (5 min) before a sustained inhibition (60 min); the inhibitory effect was mimicked by the diacylglycerol 1-oleoyl-2-acetyl-glycerol. Exogenous arachidonic acid had only a small and transient inhibitory effect on cAMP-formation. We conclude, that EGF inhibits cAMP-formation by a raise of intracellular Ca++, as well as by the direct activation of proteinkinase C, indicating, that a phosphorylated product could be a mediator for the inhibition of adenylate cyclase.

Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++. Publishing Authors By Initials

W Greil,G Niedernhuber,D Stübner,R Gärtner,

For similar endocrine system: endocrine glands: thyroid gland research abstracts see: endocrine system: endocrine glands: thyroid gland research

PUBMED ID PMID:

MEDLINE DATE:

Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta endocrinologica. Supplementum

VOLUME: 281

Page Numbers: 267-9

Journal Abbreviation:

ISSN: 0300-9750

DAY: 12

MONTH: 02

YEAR: 1987

Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370313

Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++. Keywords Mesh Terms:

KEYWORDS: Thyroid Gland

MESH TERMS: metabolism

Chemical & Substance for Abstract: Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++. Information

Substance Name: Calcium

Registry Number: 7440-70-2

Grant and Affiliation Information for Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++.

AFFILIATION:

Country: DENMARK

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Acta Endocrinol Suppl (Copenh)

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++ Related Publications

• 100 years of animal welfare regulation and of experiments with animals in Germany, effects and reasons.
• A blue light inducible two-component signal transduction system in the plant pathogen Pseudomonas syringae pv. tomato.
• A new leukoencephalopathy with bilateral anterior temporal lobe cysts.
• Acute motor and sensory axonal neuropathy (AMSAN) in a 15-year-old boy presenting with severe pain and distal muscle weakness.
• CD117 immunoexpression in canine mast cell tumours: correlations with pathological variables and proliferation markers.
• Complicated hereditary spastic paraplegia with thin corpus callosum (HSP-TCC) and childhood onset.
• Diagnostic difficulties in childhood bilateral thalamic astrocytomas.
• Domain interaction in cyanobacterial phytochromes as a prerequisite for spectral integrity.
• Effects of cage enrichment on territorial aggression and stress physiology in male laboratory mice.
• Enhanced Ras activity preserves dendritic size and extension as well as synaptic contacts of neurons after functional deprivation in synRas mice.
• GJA12 mutations are a rare cause of Pelizaeus-Merzbacher-like disease.
• Immunohistochemical characterization of a sebaceous gland carcinoma in a gerbil (Meriones unguiculatus).
• Inhibition of cAMP formation by EGF in thyroid follicles is mediated by intracellular Ca++.
• Molecular analysis of SUMF1 mutations: stability and residual activity of mutant formylglycine-generating enzyme determine disease severity in multiple sulfatase deficiency.
• Mutation analysis of the M6b gene in patients with Pelizaeus-Merzbacher-like syndrome.
• Pitfall in metabolic screening in a patient with fatal peroxisomal beta-oxidation defect.
• Polymer microfabrication technologies for microfluidic systems.
• Regular molecular nano-dot patterns for RW-data storage in the optical near field.
• Retrobulbar abscess in a neonate.
• Shedding (blue) light on algal gene expression.
• Splenic hamartomas in a dog.
• [Anesthesia nursing. Stress in emergency interventions]
• [Current condition of diagnosis and therapy of overactive urinary bladder in Czech Republic]
• [Cytomegalic virus infections in pregnancy and in the newborn]
• [Immunohistological findings in non-glomerulonephritic renal disease (author's transl)]
• [Morphology of malignant lymphoma]
• [Nephropathy in pregnancy--an endothelial lesion?]
• [Osteoporosis in the elderly--diagnosis and treatment]
• [Relationship between the endocrine system and the sociologic situation in mass breeding]
• [Results of conservative non-pharmacological therapy in female patients with urinary incontinence]