Inhibition of 6-methylsalicyclic acid synthesis by the antibiotic cerulenin.

Inhibition of 6-methylsalicyclic acid synthesis by the antibiotic cerulenin. Research Abstract Details 

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Inhibition of 6-methylsalicyclic acid synthesis by the antibiotic cerulenin. Abstract Text:

H Ohno,T Ohno,J Awaya,S Omura,

Cerulenin, a specific inhibitor of beta-ketoacyl-(acyl carrier protein) synthetase [EC 2.3.1.41] and 3-hydroxy-3-methylglutaryl-CoA synthetase [EC 4.1.3.5], was studied to determine whether it inhibits 6-methylsalicylic acid synthesis, in which so-called "polyketide" formation, a condensation step similar to that in fatty acid synthesis, is involved. In fact, 100 mug/ml (4.5 X 10(-4) M) of cerulenin inhibited 60% of 6-methylsalicylic acid synthetase activity and 68% of fatty acid synthetase activity of Penicillium urticae.

Inhibition of 6-methylsalicyclic acid synthesis by the antibiotic cerulenin. Publishing Authors By Initials

H Ohno,T Ohno,J Awaya,S Omura,

For similar organic chemicals: carboxylic acids: acids, carbocyclic: benzoic acids: hydroxybenzoic acids: salicylic acids: salicylic acid: salicylates research abstracts see: organic chemicals: carboxylic acids: acids, carbocyclic: benzoic acids: hydroxybenzoic acids: salicylic acids: salicylic acid: salicylates research

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Inhibition of 6-methylsalicyclic acid synthesis by the antibiotic cerulenin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 78

Page Numbers: 1149-52

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Dec

YEAR: 1975

Inhibition of 6-methylsalicyclic acid synthesis by the antibiotic cerulenin. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Inhibition of 6-methylsalicyclic acid synthesis by the antibiotic cerulenin. Keywords Mesh Terms:

KEYWORDS: Salicylates

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Inhibition of 6-methylsalicyclic acid synthesis by the antibiotic cerulenin. Information

Substance Name: Fatty Acid Synthetase Complex

Registry Number: EC 6.-

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Country: JAPAN

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MEDLINETA: J Biochem

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