Inheritance patterns of transcript levels in F1 hybrid mice.

Inheritance patterns of transcript levels in F1 hybrid mice. Research Abstract Details 

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Inheritance patterns of transcript levels in F1 hybrid mice. Abstract Text:

Xiangqin Cui,Jason Affourtit,Keith R Shockley,Yong Woo,Gary A Churchill,

Genetic analysis of transcriptional regulation is a rapidly emerging field of investigation that promises to shed light on the regulatory networks that control gene expression. Although a number of such studies have been carried out, the nature and extent of the heritability of gene expression traits have not been well established. We describe the inheritance of transcript levels in liver tissue in the first filial (F1) generation of mice obtained from reciprocal crosses between the common inbred strains A/J and C57BL/6J. We obtain estimates of genetic and technical variance components from these data and demonstrate that shrinkage estimators can increase detectable heritability. Estimates of heritability vary widely from transcript to transcript, with one-third of transcripts showing essentially no heritability (<0.01) and one-quarter showing very high heritability (>0.50). Roughly half of all transcripts are differentially expressed between the two parental strains. Most transcripts show an additive pattern of inheritance. Dominance effects were observed for 20% of transcripts and a small number of transcripts were identified as showing an overdominance mode of inheritance. In addition, we identified 314 transcripts with expression levels that differ between the reciprocal F1 animals. These genes may be related to maternal effect.

Inheritance patterns of transcript levels in F1 hybrid mice. Publishing Authors By Initials

X Cui,J Affourtit,KR Shockley,Y Woo,GA Churchill,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research

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Inheritance patterns of transcript levels in F1 hybrid mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Genetics

VOLUME: 174

Page Numbers: 627-37

Journal Abbreviation: Genetics

ISSN: 0016-6731

DAY: 3

MONTH: 08

YEAR: 2006

Inheritance patterns of transcript levels in F1 hybrid mice. Information

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LANGUAGE: eng

NlmUniqueID: 374636

Inheritance patterns of transcript levels in F1 hybrid mice. Keywords Mesh Terms:

KEYWORDS: RNA, Messenger

MESH TERMS: genetics

Chemical & Substance for Abstract: Inheritance patterns of transcript levels in F1 hybrid mice. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Inheritance patterns of transcript levels in F1 hybrid mice.

AFFILIATION: Department of Biostatistics, Section on Statistical Genetics, Department of Medicine, Genetic and Translational Medicine Division, University of Alabama, Alabama 35294, USA. xcui@uab.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL55001

ACRONYM: HL

MEDLINETA: Genetics

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