Inhaled anesthesia: the original closed-loop drug administration paradigm.

Inhaled anesthesia: the original closed-loop drug administration paradigm. Research Abstract Details 

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Inhaled anesthesia: the original closed-loop drug administration paradigm. Abstract Text:

We administer anesthetics to obtain therapeutic effects and minimize untoward side effects. Anesthetists can precisely control inhaled anesthetic concentrations by controlling end-tidal volatile anesthetic concentrations. This degree of control eliminates the need for closed-loop inhaled anesthetic systems. The low solubility of modern inhaled anesthetics adds to the stability and control of the anesthetic state; the effective inhaled concentration varies little during maintenance of anesthesia unless altered by the anesthetist. A less precise closed-loop system applies a processed electroencephalogram (EEG) to assess depth of anesthesia and enable accurate delivery of volatile and intravenous anesthetics to maintain a stable state of anesthesia.

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Inhaled anesthesia: the original closed-loop drug administration paradigm. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Clinical pharmacology and therapeutics

VOLUME: 84

Page Numbers: 15-8

Journal Abbreviation: Clin. Pharmacol. Ther.

ISSN: 1532-6535

DAY: 19

MONTH: Jul

YEAR: 2008

Inhaled anesthesia: the original closed-loop drug administration paradigm. Information

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LANGUAGE: eng

NlmUniqueID: 372741

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Grant and Affiliation Information for Inhaled anesthesia: the original closed-loop drug administration paradigm.

AFFILIATION: Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Dhanesh-Gupta@northwestern.edu

Country: United States

AGENCY: United States NIGMS

GRANT: 1P01GM47818

ACRONYM: GM

MEDLINETA: Clin Pharmacol Ther

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