Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice.

Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Abstract Text:

Michael T Kleinman,Constantinos Sioutas,John R Froines,Elinor Fanning,Ali Hamade,Loyda Mendez,Dianne Meacher,Michael Oldham,

Motor vehicle exhaust emissions are known to exacerbate asthma and other respiratory diseases. Several studies have demonstrated significant associations between living near highly trafficked roadways and increased incidence of asthma and increased severity of asthma-related symptoms, medication usage, and physician visits. This study tested the hypotheses that (1) exposure to particulate matter (PM) near a heavily trafficked Los Angeles freeway would enhance inflammatory and allergic responses in ovalbumin (OVA)-sensitized BALB/c mice compared to sensitized, clean air controls, and (2) there would be differences in response at two distances downwind of heavily traveled freeways because of greater toxicity of PM closest to the freeway. An ambient particle concentrator was used to expose ovalbumin (OVA)-treated BALB/c mice to purified air, to concentrated fine ambient particles, and to concentrated ultrafine airborne particles (CAPs) at 2 distances, 50 m and 150 m, downwind of a roadway that is impacted by emissions from both heavy-duty diesel and light duty gasoline vehicles. Tissues and biological fluids from the mice were analyzed after exposures for 5 days/wk in 2 consecutive weeks. The biomarkers of allergic or inflammatory responses that were assessed included cytokines released by Type 2 T-helper cells (interleukin [IL]-5 and IL-13), OVA-specific immunoglobulin E (IgE), OVA-specific immunoglobulin G1 (IgG1), and pulmonary infiltration of polymorphonuclear leukocytes and eosinophils. IL-5 and IgG1 were significantly increased in mice exposed to CAPs 50 m downwind of the road, compared to responses in mice exposed to purified air, providing evidence of allergic response. No significant increases in allergy-related responses were observed in mice exposed to CAPs 150 m downwind of the road. The biological responses at the 50-m site were significantly associated with organic and elemental carbon components of fine and ultrafine particles (p < or = .05). The primary source of these contaminants at the roadway sites was motor vehicle emissions, suggesting that particulate matter from motor vehicle fuel combustion could exert adjuvant effects and promote the development of allergic airway diseases.

Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Publishing Authors By Initials

MT Kleinman,C Sioutas,JR Froines,E Fanning,A Hamade,L Mendez,D Meacher,M Oldham,

For similar complex mixtures: vehicle emissions research abstracts see: complex mixtures: vehicle emissions research

PUBMED ID PMID:

MEDLINE DATE:

Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Inhalation toxicology

VOLUME: 19 Suppl 1

Page Numbers: 117-26

Journal Abbreviation:

ISSN: 1091-7691

DAY: 19

MONTH: 11

YEAR: 2007

Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8910739

Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Keywords Mesh Terms:

KEYWORDS: Vehicle Emissions

MESH TERMS: toxicity

Chemical & Substance for Abstract: Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. Information

Substance Name: Vehicle Emissions

Registry Number: 0

Grant and Affiliation Information for Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice.

AFFILIATION: Department of Community and Environmental Medicine, University of California, Irvine, California 92697-1825, USA. mtkleinm@uci.edu

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Inhal Toxicol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice Related Publications

• An iterative method for training multilayer networks with threshold functions.
• Aneurysm of the ductus arteriosus in the neonate.
• Benchmarking a novel ultrasound-CT fusion system for respiratory motion management in radiotherapy: assessment of spatio-temporal characteristics and comparison to 4DCT.
• Biotherapy: the fourth modality of cancer treatment.
• Cardiac volvulus: plain film recognition of an often fatal condition.
• Cervical spine ROM measurements: optimizing the testing protocol by using a 3D ultrasound-based motion analysis system.
• Comorbid personality disorder and treatment use in a community sample of youths: a 20-year follow-up.
• Comparison of Analytical and Numerical Particle Deposition Using Commercial CFD Packages: Impaction and Sedimentation.
• Corrections to "image recovery and segmentation using competitive learning in a layered network.
• Damage-Limited Lifetime of 193-nm Lithography Tools as a Function of System Variables.
• Drosophila aging 2006/2007.
• Editorial: 2008: state of affairs for cancer biotherapy & radiopharmaceuticals.
• Functional imaging in bulk tissue specimens using optical emission tomography: fluorescence preservation during optical clearing.
• High-dose methotrexate in combination chemotherapy for small cell lung cancer.
• INSULIN TREATMENT OF SCHIZOPHRENIA--A CONTROLLED STUDY.
• Image recovery and segmentation using competitive learning in a layered network.
• Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice.
• Insulin treatment of schizophrenia. A three-year follow-up of a controlled study.
• Launching DSM-V.
• Managing broiler litter application rate and grazing to decrease watershed runoff losses.
• Managing broiler litter application rate and grazing to decrease watershed runoff losses.
• Mycetoma of the lung in a cavity that developed from a gunshot wound.
• Preface.
• Quantitative determination of lysozyme-ligand binding in the solution and gas phases by electrospray ionisation mass spectrometry.
• Research and treatment synergism.
• The aetiology of depression and anxiety.
• The brighter side.
• The problem of consistent radiological diagnosis in coalminers' pneumoconiosis; an experimental study.
• The psychophysics of clinical pain.
• The reliability of isometric strength and fatigue measures in patients with knee osteoarthritis.