Inhalation injury in severely burned children does not augment the systemic inflammatory response.

Inhalation injury in severely burned children does not augment the systemic inflammatory response. Research Abstract Details 

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Inhalation injury in severely burned children does not augment the systemic inflammatory response. Abstract Text:

Celeste C Finnerty,David N Herndon,Marc G Jeschke,

INTRODUCTION: Inhalation injury in combination with a severe thermal injury increases mortality. Alterations in inflammatory mediators, such as cytokines, contribute to the incidence of multi-organ failure and mortality. The aim of the present study was to determine the effect of inhalation injury on cytokine expression in severely burned children. METHODS: Thirty severely burned pediatric patients with inhalation injury and 42 severely burned children without inhalation injury were enrolled in the study. Inhalation injury was diagnosed by bronchoscopy during the first operation. Blood was collected within 24 hours of admission and again at five to seven days following admission. Cytokine expression was profiled using multi-plex antibody-coated beads. Significance was accepted at a p value of less than 0.05. RESULTS: The mean percentages of total body surface area burned were 67% +/- 4% (56% +/- 6%, third-degree burns) in the inhalation injury group and 60% +/- 3% (45% +/- 3%, third-degree burns) in the non-inhalation injury group (p value not significant [NS]). Mean age was 9 +/- 1 years in the inhalation injury group and 8 +/- 1 years in the non-inhalation injury group (p value NS). Time from burn to admission in the inhalation injury group was 2 +/- 1 days compared to 3 +/- 1 days in the non-inhalation injury group (p value NS). Mortalities were 40% in the inhalation injury group and 12% in the non-inhalation injury group (p < 0.05). At the time of admission, serum interleukin (IL)-7 was significantly increased in the non-inhalation injury group, whereas IL-12p70 was significantly increased in the inhalation injury group compared to the non-inhalation injury group (p < 0.05). There were no other significant differences between groups. Five to seven days following admission, all cytokines decreased with no differences between the inhalation injury and non-inhalation injury cohorts. CONCLUSION: In the present study, we show that an inhalation injury causes alterations in IL-7 and IL-12p70. There were no increased levels of pro-inflammatory cytokines, indicating that an inhalation injury in addition to a burn injury does not augment the systemic inflammatory response early after burn.

Inhalation injury in severely burned children does not augment the systemic inflammatory response. Publishing Authors By Initials

CC Finnerty,DN Herndon,MG Jeschke,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research

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MEDLINE DATE:

Inhalation injury in severely burned children does not augment the systemic inflammatory response. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Critical care (London, England)

VOLUME: 11

Page Numbers: R22

Journal Abbreviation:

ISSN: 1466-609X

DAY: 3

MONTH: 12

YEAR: 2007

Inhalation injury in severely burned children does not augment the systemic inflammatory response. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9801902

Inhalation injury in severely burned children does not augment the systemic inflammatory response. Keywords Mesh Terms:

KEYWORDS: Prospective Studies

MESH TERMS: metabolism

Chemical & Substance for Abstract: Inhalation injury in severely burned children does not augment the systemic inflammatory response. Information

Substance Name: Interleukin-12

Registry Number: 187348-17-0

Grant and Affiliation Information for Inhalation injury in severely burned children does not augment the systemic inflammatory response.

AFFILIATION: Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA. ccfinner@utmb.edu

Country: England

AGENCY: United States NIGMS

GRANT: T32-GM08256

ACRONYM: GM

MEDLINETA: Crit Care

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