Infusional 5-fluorouracil and cisplatin as first-line chemotherapy in patients with carcinoma of unknown primary site.

Infusional 5-fluorouracil and cisplatin as first-line chemotherapy in patients with carcinoma of unknown primary site. Research Abstract Details 

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Infusional 5-fluorouracil and cisplatin as first-line chemotherapy in patients with carcinoma of unknown primary site. Abstract Text:

Hitoshi Kusaba,Yoshihiro Shibata,Shuji Arita,Hiroshi Ariyama,Eishi Baba,Kenji Mitsugi,Mine Harada,Shuji Nakano,Hitoshi Kusaba,Yoshihiro Shibata,Shuji Arita,Hiroshi Ariyama,Eishi Baba,Kenji Mitsugi,Mine Harada,Shuji Nakano,

A combination chemotherapy of 5-fluorouracil (5-FU) and cisplatin (CDDP) has demonstrated activities in various malignancies, including head and neck, lung, esophageal, gastric, and pancreatic cancers. We reviewed our experience of 11 patients diagnosed as carcinoma of unknown primary site (CUPS), who were treated with infusional 5-FU and CDDP between January 1998 and December 2005. The median number of cycles administered was three (range: 1-12). All patients had measurable disease. Six partial responses were obtained (response rate: 54.5%, 95% confidence interval: 23.4-83.3%). The median survival time for all patients was 10 mo (range, 2-37 mo). The median time to disease progression was 3 mo (range, 1-6 mo). This regimen was well tolerated, with grade 3-4 neutropenia (two patients), febrile neutropenia (one patient), grade 3 nausea/vomiting (one patient), and grade 3 stomatitis (two patients). Grade 2 leukoencephalopathy was observed in one patient. No treatment-related death was observed. The combination chemotherapy of infusional 5-FU and CDDP was feasible and tolerated with promising activity for CUPS.

Infusional 5-fluorouracil and cisplatin as first-line chemotherapy in patients with carcinoma of unknown primary site. Publishing Authors By Initials

H Kusaba,Y Shibata,S Arita,H Ariyama,E Baba,K Mitsugi,M Harada,S Nakano,H Kusaba,Y Shibata,S Arita,H Ariyama,E Baba,K Mitsugi,M Harada,S Nakano,

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Infusional 5-fluorouracil and cisplatin as first-line chemotherapy in patients with carcinoma of unknown primary site. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Medical oncology (Northwood, London, England)

VOLUME: 24

Page Numbers: 259-64

Journal Abbreviation: Med. Oncol.

ISSN: 1357-0560

DAY: 12

MONTH: 09

YEAR: 2007

Infusional 5-fluorouracil and cisplatin as first-line chemotherapy in patients with carcinoma of unknown primary site. Information

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LANGUAGE: eng

NlmUniqueID: 9435512

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AFFILIATION: First Department of Medicine and Department of Bio systemic Science of Medicine, Kyushu University Graduate School of Medicine, Fukuoka, Japan. hkusaba@intmed1.med.kyushu-u.ac.jp

Country: United States

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MEDLINETA: Med Oncol

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