Informed consent as a source of bias in clinical research.

Informed consent as a source of bias in clinical research. Research Abstract Details 

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Informed consent as a source of bias in clinical research. Abstract Text:

Clinical observation suggested that schizophrenic patients more often refused to participate in experiments. In two studies psychiatric patient volunteers and nonvolunteers were compared on discharge diagnoses (psychiatric and medical), medication given, demographic measures, and hospitalization characteristics. In each study, patients with paranoid schizophrenia were more likely to refuse participation. Also, in each study, volunteers received more benzodiazepines and more nonpsychiatric medication. The latter difference could not be explained on the bases of rated severity of or probability of drug use in diagnosed medical illnesses, or number of medical illnesses. Characteristics of schizophrenic patients such as suspiciousness, negativism, and ambivalence were suggested as possible sources of their refusal to participate. Nonvolunteers were suggested to be less agreeable and compliant in general, and perhaps less likable, possibly explaining their receiving fewer benzodiazepines and nonpsychiatric medications. Attempts to characterize and correct the volunteer bias should be made, including offering tangible reward.

Informed consent as a source of bias in clinical research. Publishing Authors By Initials

For similar behavioral disciplines and activities: schizophrenic psychology research abstracts see: behavioral disciplines and activities: schizophrenic psychology research

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Informed consent as a source of bias in clinical research. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Psychiatry research

VOLUME: 12

Page Numbers: 313-20

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 17

MONTH: Aug

YEAR: 1984

Informed consent as a source of bias in clinical research. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Informed consent as a source of bias in clinical research. Keywords Mesh Terms:

KEYWORDS: Schizophrenic Psychology

MESH TERMS: psychology

Chemical & Substance for Abstract: Informed consent as a source of bias in clinical research. Information

Substance Name: Benzodiazepines

Registry Number: 0

Grant and Affiliation Information for Informed consent as a source of bias in clinical research.

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Country: NETHERLANDS

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MEDLINETA: Psychiatry Res

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