Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air.

Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air. Research Abstract Details 

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Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air. Abstract Text:

Michael S Davis,Caroline C Williams,James H Meinkoth,Jerry R Malayer,Christopher M Royer,Katherine K Williamson,Erica C McKenzie,

OBJECTIVE: To determine effects of exercise performed while breathing cold air on expression of cytokines and influx of neutrophils in airways of horses. ANIMALS: 9 adult horses. PROCEDURES: In a crossover study, bronchoalveolar lavage fluid (BALF) was obtained 24 and 48 hours after each of 2 submaximal exercise sessions performed by horses while breathing warm (25 degrees C) or cold (-5 degrees C) air. Total and differential nucleated cell counts were determined for each BALF sample. Relative mRNA expression of cytokines in BALF cells was quantified by use of a reverse transcription-PCR assay. RESULTS: Horses had a modest but significant influx of neutrophils into the airways 24 hours after a single exercise session while breathing cold air. No other cell types were increased at 24 or 48 hours after exercising while breathing cold air. Continued increases in expression of cytokines interleukin (IL)-5 and-10 as well as proinflammatory cytokines IL-1, -6, and -8 were detected 24 hours after exercising while breathing cold air. Forty-eight hours after exercising while breathing cold air, expression of IL-10 was still higher than that for IL-10 after horses exercised while breathing warm air. Expression of tumor necrosis factor-alpha was significantly increased at 48 hours after exercising while breathing cold air. CONCLUSIONS AND CLINICAL RELEVANCE: Exposure of intrapulmonary airways to cold air alters immunologic responses of horses for at least 48 hours. The increased expression of cytokines that suppress cell-mediated immunity may predispose athletes to viral infections of the respiratory tract following exercise in cold weather.

Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air. Publishing Authors By Initials

MS Davis,CC Williams,JH Meinkoth,JR Malayer,CM Royer,KK Williamson,EC McKenzie,

For similar nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research abstracts see: nucleic acids, nucleotides, and nucleosides: nucleic acids: rna: rna, messenger research

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Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of veterinary research

VOLUME: 68

Page Numbers: 185-9

Journal Abbreviation: Am. J. Vet. Res.

ISSN: 0002-9645

DAY: 3

MONTH: Feb

YEAR: 2007

Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air. Information

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LANGUAGE: eng

NlmUniqueID: 375011

Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air. Keywords Mesh Terms:

KEYWORDS: RNA, Messenger

MESH TERMS: metabolism

Chemical & Substance for Abstract: Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air.

AFFILIATION: Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.

Country: United States

AGENCY: United States NCRR

GRANT: R01RR016109-01A2

ACRONYM: RR

MEDLINETA: Am J Vet Res

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