Influenza hemagglutinin vaccine with poly(gamma-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity.

Influenza hemagglutinin vaccine with poly(gamma-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity. Research Abstract Details 

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Influenza hemagglutinin vaccine with poly(gamma-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity. Abstract Text:

Shigefumi Okamoto,Hironori Yoshii,Takami Akagi,Mitsuru Akashi,Toyokazu Ishikawa,Yoshinobu Okuno,Michiaki Takahashi,Koichi Yamanishi,Yasuko Mori,Shigefumi Okamoto,Hironori Yoshii,Takami Akagi,Mitsuru Akashi,Toyokazu Ishikawa,Yoshinobu Okuno,Michiaki Takahashi,Koichi Yamanishi,Yasuko Mori,

Subcutaneous immunization with an influenza hemagglutinin (HA) vaccine can induce the production of virus-neutralizing antibodies, but not a cell-mediated immune response. Here we tested whether amphiphilic poly(gamma-glutamic acid)-graft-l-phenylalanine copolymers (gamma-PGA-NPs), which are derived from a bacterial capsular exopolymer produced by certain Bacillus natto strains, were an effective adjuvant for systemic influenza HA vaccination. Subcutaneous immunization with a mixture of HA vaccine and gamma-PGA-NPs induced higher mononuclear cell proliferation and the production of gamma-interferon (IFN-gamma), interleukin (IL)-4, and IL-6 upon HA restimulation, and enhanced not only anti-HA neutralizing antibody production but also the influenza virus-specific cell-mediated immune response, including CTL activity, compared with immunization with HA alone or a mixture of HA and aluminum adjuvant. HA vaccine with gamma-PGA-NPs protected mice against challenges with lethal doses of homologous influenza virus. The results indicate that adding gamma-PGA-NPs to the HA vaccine promotes effective protection and identifies gamma-PGA-NPs as a new, effective, and potent candidate adjuvant for a subcutaneous influenza virus vaccine.

Influenza hemagglutinin vaccine with poly(gamma-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity. Publishing Authors By Initials

S Okamoto,H Yoshii,T Akagi,M Akashi,T Ishikawa,Y Okuno,M Takahashi,K Yamanishi,Y Mori,S Okamoto,H Yoshii,T Akagi,M Akashi,T Ishikawa,Y Okuno,M Takahashi,K Yamanishi,Y Mori,

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Influenza hemagglutinin vaccine with poly(gamma-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Vaccine

VOLUME: 25

Page Numbers: 8270-8

Journal Abbreviation: Vaccine

ISSN: 0264-410X

DAY: 11

MONTH: 10

YEAR: 2007

Influenza hemagglutinin vaccine with poly(gamma-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity. Information

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LANGUAGE: eng

NlmUniqueID: 8406899

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Grant and Affiliation Information for Influenza hemagglutinin vaccine with poly(gamma-glutamic acid) nanoparticles enhances the protection against influenza virus infection through both humoral and cell-mediated immunity.

AFFILIATION: Laboratory of Virology and Vaccinology, Division of Biomedical Research, National Institute of Biomedical Innovation, 7-6-8 Saito-Asagi, Ibaraki, Osaka 567-0085, Japan.

Country: Netherlands

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MEDLINETA: Vaccine

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