Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration.

Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration. Research Abstract Details 

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Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration. Abstract Text:

Wei Wang,Soichiro Itoh,Atsushi Matsuda,Shizuko Ichinose,Kenichi Shinomiya,Yuiro Hata,Junzo Tanaka,Wei Wang,Soichiro Itoh,Atsushi Matsuda,Shizuko Ichinose,Kenichi Shinomiya,Yuiro Hata,Junzo Tanaka,

We have developed chitosan nonwoven micro/nanofiber mesh tubes and examined the effects of their mechanical strength and permeability on nerve regeneration. Chitosan nano/microfibrous tubes with a deacetylation rate (DAc) of 78% or 93% were prepared by electrospinning. A chitosan film tube with a DAc of 93% was also fabricated and combined with the nano/microfibrous tubes to form bilayered tubes with a nano/microfiber mesh inner structure and a film outer layer. Nano/microfiber mesh tubes with a DAc of 78% or 93%, bilayered tubes with a nano/microfiber mesh inner structure with a DAc of 78% or 93% and a film outer layer with a DAc of 93%, and film tubes with a DAc of 93% were each tested as bridge grafts into injured rat sciatic nerve. Isografting was performed as a control. Although the functional recovery of motor activity was delayed in each group, sensory function reemerged first in the isograft group followed by the group receiving nano/microfiber mesh tubes with a DAc of 93%. Histological analysis was consistent with these results. The chitosan nano/microfiber mesh tubes with a DAc of 93% have sufficient mechanical properties to preserve tube space, provide a better scaffold for cell migration and attachment, and facilitate humoral permeation to enhance nerve regeneration. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008.

Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration. Publishing Authors By Initials

W Wang,S Itoh,A Matsuda,S Ichinose,K Shinomiya,Y Hata,J Tanaka,W Wang,S Itoh,A Matsuda,S Ichinose,K Shinomiya,Y Hata,J Tanaka,

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Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedical materials research. Part A

VOLUME: 84

Page Numbers: 557-66

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ISSN: 1549-3296

DAY: 20

MONTH: Feb

YEAR: 2008

Influences of mechanical properties and permeability on chitosan nano/microfiber mesh tubes as a scaffold for nerve regeneration. Information

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LANGUAGE: eng

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AFFILIATION: Department of Plastic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8519, Japan.

Country: United States

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MEDLINETA: J Biomed Mater Res A

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