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Influence of upper body position on middle cerebral artery blood velocity during continuous positive airway pressure breathing.

Influence of upper body position on middle cerebral artery blood velocity during continuous positive airway pressure breathing. Research Abstract Details 

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  • Influence of upper body position on middle cerebral artery blood velocity during continuous positive airway pressure breathing. Abstract Text:

    j J ,t mantoniT Mantoni,b belhageB Belhage,f c pottF C Pott,j J ,t mantoniT Mantoni,b belhageB Belhage,f c pottF C Pott,

    Continuous positive airway pressure (CPAP) is a treatment modality for pulmonary oxygenation difficulties. CPAP impairs venous return to the heart and, in turn, affects cerebral blood flow (CBF) and augments cerebral blood volume (CBV). We considered that during CPAP, elevation of the upper body would prevent a rise in CBV, while orthostasis would challenge CBF. To determine the body position least affecting indices of CBF and CBV, the middle cerebral artery mean blood velocity (MCA V(mean)) and the near-infrared spectroscopy determined frontal cerebral hemoglobin content (cHbT) were evaluated in 11 healthy subjects during CPAP at different body positions (15 degrees head-down tilt, supine, 15 degrees, 30 degrees and 45 degrees upper body elevation). In the supine position, 10 cmH(2)O of CPAP reduced MCA V(mean) by 9 +/- 3% and increased cHbT by 4 +/- 2 micromol/L (mean +/- SEM); (P < 0.05). In the head-down position, CPAP increased cHbT to 13 +/- 2 micromol/L but left MCA V(mean) unchanged. Upper body elevation by 15 degrees attenuated the CPAP associated reduction in MCA V(mean) (-7 +/- 2%), while cHbT returned to baseline (1 +/- 2 micromol/L). With larger elevation of the upper body MCA V(mean) decreased progressively to -17 +/- 3%, while cHbT remained unchanged from baseline. These results suggest that upper body elevation by approximately 15 degrees during 10 cmH(2)O CPAP prevents an increase in cerebral blood volume with minimal effect on cerebral blood flow.

    Influence of upper body position on middle cerebral artery blood velocity during continuous positive airway pressure breathing. Publishing Authors By Initials

    j J ,t mantoniT Mantoni,b belhageB Belhage,fc pottFC Pott,j J ,t mantoniT Mantoni,b belhageB Belhage,fc pottFC Pott,

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    Influence of upper body position on middle cerebral artery blood velocity during continuous positive airway pressure breathing. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: European journal of applied physiology

    VOLUME: 101

    Page Numbers: 369-75

    Journal Abbreviation: Eur. J. Appl. Physiol.

    ISSN: 1439-6319

    DAY: 19

    MONTH: 07

    YEAR: 2007

    Influence of upper body position on middle cerebral artery blood velocity during continuous positive airway pressure breathing. Information

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    LANGUAGE: eng

    NlmUniqueID: 100954790

    Influence of upper body position on middle cerebral artery blood velocity during continuous positive airway pressure breathing. Keywords Mesh Terms:

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    Grant and Affiliation Information for Influence of upper body position on middle cerebral artery blood velocity during continuous positive airway pressure breathing.

    AFFILIATION: Bispebjerg Hospital Research Unit for Anaesthesia and Intensive Care, Department of Anaesthesia, Bispebjerg Hospital, University of Copenhagen, 2400, Copenhagen NV, Denmark. jakob.hoejlund@gmail.com

    Country: Germany

    Germany Research PublicationGermany Research Publication

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    MEDLINETA: Eur J Appl Physiol

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