Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy.

Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy. Research Abstract Details 

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Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy. Abstract Text:

PURPOSE: To evaluate the effect of topical treatment given immediately after photorefractive keratectomy. METHODS: A prospective, randomized, double-blind clinical trial was performed on 60 eyes from 60 patients to evaluate the effects of topical diclofenac, dexamethasone and placebo (BSS) on epithelial wound healing, inflammation and duration of pain in the 3 days following surgery. RESULTS: Topical diclofenac and dexamethasone as one group significantly retarded epithelial healing and presented a higher number of central islands than the placebo, 3 days after surgery. Topical diclofenac retarded epithelial healing significantly more than dexamethasone. Anterior chamber flare was elevated after surgery without significant differences between treatment groups. Diclofenac showed a tendency to reduce the duration of pain following the procedure, although not significantly. CONCLUSIONS: Postoperative topical diclofenac and dexamethasone used during the first three days following photorefractive keratectomy may affect the epithelial healing and early visual rehabilitation.

Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy. Publishing Authors By Initials

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: regeneration: wound healing research

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Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta ophthalmologica Scandinavica

VOLUME: 77

Page Numbers: 135-8

Journal Abbreviation: Acta Ophthalmol Scand

ISSN: 1395-3907

DAY: 17

MONTH: Apr

YEAR: 1999

Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy. Information

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LANGUAGE: eng

NlmUniqueID: 9507578

Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy. Keywords Mesh Terms:

KEYWORDS: Wound Healing

MESH TERMS: drug effects

Chemical & Substance for Abstract: Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy. Information

Substance Name: Dexamethasone

Registry Number: 50-02-2

Grant and Affiliation Information for Influence of topical treatment on epithelial wound healing and pain in the early postoperative period following photorefractive keratectomy.

AFFILIATION: St. Erik's Eye Hospital (Karolinska Institute), Stockholm, Sweden.

Country: DENMARK

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MEDLINETA: Acta Ophthalmol Scand

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